T1692

Tianeptine sodium salt hydrate

≥98% (HPLC), opioid receptor agaonist, powder

• Synonim(y): 7-[(3-Chloro-6,11-dihydro-6-methyl-dibenzo[c,f][1,2]thiazepine-11-yl)amino]heptanoic acid S,S dioxide sodium salt hydrate
• Wzór empiryczny (zapis Hilla): C₂₁H₂₄ClN₂NaO₄S · xH₂O
• Numer CAS: 30123-17-2
• Masa cząsteczkowa: 458.93 (anhydrous basis)
• UNSPSC Code: 12352200
• PubChem Substance ID: 24899985
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Właściwości

• Nazwa produktu: Tianeptine sodium salt hydrate, ≥98% (HPLC), powder
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to tan
• solubility: DMSO: ≥20 mg/mL
• originator: Servier
• storage temp.: room temp
• SMILES string: O.[Na+].CN1c2ccccc2C(NCCCCCCC([O-])=O)c3ccc(Cl)cc3S1(=O)=O
• InChI: 1S/C21H25ClN2O4S.Na.H2O/c1-24-18-9-6-5-8-16(18)21(23-13-7-3-2-4-10-20(25)26)17-12-11-15(22)14-19(17)29(24,27)28;;/h5-6,8-9,11-12,14,21,23H,2-4,7,10,13H2,1H3,(H,25,26);;1H2/q;+1;/p-1
• InChI key: HNTRDGDHBBFLPG-UHFFFAOYSA-M

Opis

General description

Tianeptine is a μ-opioid receptor (MOR)[1] as well as a δ-opioid receptor (DOR) agonist.[1]

Application

Tianeptine sodium salt hydrate has been used as a selective serotonin reuptake enhancer (SSRE) positive control during serotonin transporter (SERT) assay in human embryonic kidney 293 cell lines.[2]

Biochem/physiol Actions

Tianeptine is a tricyclic antidepressant that enhances serotonin uptake. This drug can affect neuroprotection, neuronal excitability, memory and anxiety[3]. However, tianeptine is not linked to adverse psychomotor, cognitive, cardiovascular, sleep and bodyweight effects. The drug has a low tendency for abuse and has a positive pharmacokinetic profile[4].

Tianeptine is least involved in drug interaction as it is not metabolized by cytochrome P450 system in the liver.[5] In hippocampus and amygdala, tianeptine is involved in glutamatergic transmission processes and elicits neuroplasticity.[1]

Features and Benefits

This compound was developed by Servier. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Preparation Note

Tianeptine sodium salt hydrate is soluble in DMSO at a concentration that is greater than or equal to 20 mg/ml.

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)