SRP4503

FABP3 human

recombinant, expressed in E. coli, ≥98% (SDS-PAGE)

• Synonim(y): Fatty acid-binding protein heart, H-FABP, Heart-type fatty acid-binding protein, M-FABP, Mammary-derived growth inhibitor, Muscle fatty acid-binding protein
• UNSPSC Code: 12352200
• NACRES: NA.32
• MDL number: MFCD00285932
• Form: lyophilized
• Assay: ≥98% (SDS-PAGE)
• Biological source: human
• Recombinant: expressed in E. coli
• Mol wt: ~19 kDa

Właściwości

• biological source: human
• recombinant: expressed in E. coli
• assay: ≥98% (SDS-PAGE)
• form: lyophilized
• mol wt: ~19 kDa
• packaging: pkg of 100 μg
• storage condition: avoid repeated freeze/thaw cycles
• impurities: endotoxin, tested
• NCBI accession no.: P05413
• UniProt accession no.: P05413
• shipped in: wet ice
• storage temp.: −20°C
• Gene Information: human ... FABP3(2170)

Opis

General description

Fatty acid binding proteins (FABPs) are intracellular proteins with a low molecular weight. They exhibit high affinity for small lipophilic ligands. FABP-3 is expressed in the skeletal muscle, heart, brain and brown adipose tissue. The gene encoding it is localized on human chromosome 1p35.[1]

Biochem/physiol Actions

Studies suggest that fatty acid binding protein (FABPs) are involved in the uptake and metabolism of fatty acids, maintenance of cellular membrane fatty acids levels, intracellular trafficking, modulation of specific enzymes of lipid metabolic pathways, as well as in the modulation of cell growth and differentiation. FABPs have been associated with diabetes, obesity, atherosclerosis and brain function. FABP-3 has a role in glucose and lipid metabolism. It also modulates polysaturated fatty acid uptake and metabolism in neurons. The protein has been associated with schizophrenia, Down′s syndrome, Alzheimer′s disease and autism spectrum disorder.[1]

Physical form

Sterile filtered and Lyophilized without additives.

Preparation Note

Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.

Reconstitute in water to a concentration of 0.1-1.0 mg/mL. This solution can then be diluted into other aqueous buffers

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 13 - Non Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable