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Kluczowe dokumenty
S7821
Sulfadoxin
≥95% (TLC)
Synonim(y):
4-Amino-N-(5,6-dimethoxy-4-pyrimidinyl)benzenesulfonamide, Sulfadoxine
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About This Item
Wzór empiryczny (zapis Hilla):
C12H14N4O4S
Numer CAS:
Masa cząsteczkowa:
310.33
Beilstein:
625453
Numer WE:
Numer MDL:
Kod UNSPSC:
51101500
Identyfikator substancji w PubChem:
NACRES:
NA.85
Polecane produkty
Próba
≥95% (TLC)
Formularz
powder
kolor
white
rozpuszczalność
ethanol: NH4OH (9:1): soluble 20 mg/mL
spektrum działania antybiotyku
parasites
Tryb działania
enzyme | inhibits
ciąg SMILES
COc1ncnc(NS(=O)(=O)c2ccc(N)cc2)c1OC
InChI
1S/C12H14N4O4S/c1-19-10-11(14-7-15-12(10)20-2)16-21(17,18)9-5-3-8(13)4-6-9/h3-7H,13H2,1-2H3,(H,14,15,16)
Klucz InChI
PJSFRIWCGOHTNF-UHFFFAOYSA-N
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Opis ogólny
Chemical structure: sulfonamide
Zastosowanie
Sulfadoxine is a sulfonamide antibiotic used in combination with pyrimethamine for the treatment or prevention of malaria. It is also used to treat various infections in livestock. Sulfadoxine and pyrimethamine is indicated for the treatment of Plasmodium falciparum malaria in patients where chloroquine resistance is suspected. It is used to study infections caused by Toxoplasma gondii and has been used to prevent infections after surgery during animal studies.
Działania biochem./fizjol.
Sulfadoxine is a sulfonamide antibacterial that inhibits dihydropteroate synthase (DHPS), an enzyme that transforms 4-aminobenzoic acid (PABA) in the synthesis of dihydropteroic acid. This enzyme is also a component of the folate metabolic pathway and is upstream of dihydrofolate reductase (DHFR).
Inne uwagi
Keep container tightly closed in a dry and well-ventilated place.Storage class (TRGS 510): Non Combustible Solids
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