S3378

Spironolactone

97.0-103.0% (HPLC), powder, aldosterone receptor antagonist

• Synonim(y): 4-Pregnen-21-oic acid-17α-ol-3-one-7α-thiol γ-lactone 7-acetate, 7α-(Acetylthio)-17α-hydroxy-3-oxopregn-4-ene-21-carboxylic acid γ-lactone
• Wzór empiryczny (zapis Hilla): C₂₄H₃₂O₄S
• Numer CAS: 52-01-7
• Masa cząsteczkowa: 416.57
• NACRES: NA.77
• PubChem Substance ID: 24277736
• UNSPSC Code: 51111800
• EC Number: 200-133-6
• MDL number: MFCD00082250
• Assay: 97.0-103.0%
• Quality level: 200

Właściwości

• Nazwa produktu: Spironolactone, 97.0-103.0%
• Quality Level: 200
• assay: 97.0-103.0%
• mp: 207-208 °C (lit.)
• solubility: chloroform: complete 50 mg/ml, clear, faintly yellow
• SMILES string: CC(=O)S[C@@H]1CC2=CC(=O)CC[C@]2(C)[C@H]3CC[C@@]4(C)[C@@H](CC[C@@]45CCC(=O)O5)[C@H]13
• InChI: 1S/C24H32O4S/c1-14(25)29-19-13-15-12-16(26)4-8-22(15,2)17-5-9-23(3)18(21(17)19)6-10-24(23)11-7-20(27)28-24/h12,17-19,21H,4-11,13H2,1-3H3/t17-,18-,19+,21+,22-,23-,24+/m0/s1
• InChI key: LXMSZDCAJNLERA-ZHYRCANASA-N
• Gene Information: human ... HSD17B1(3292), NR3C2(4306) ; rat ... Ar(24208)

Opis

Application

Spironolactone was added to rat diet to study the effect of long-term spironolactone use on renal function.[1][2]

Biochem/physiol Actions

Spironolactone is a competitive aldosterone receptor antagonist. Used as potassium sparing diuretic.

Spironolactone reduces aldosterone-induced potassium/magnesium loss and myocardial fibrosis.[3] It reduces hypertension,[4] improves the endothelial function and reduces the overall morbidity and mortality in patients with chronic heart failure.[5] Spironolactone improves nitric oxide bioactivity and vascular endothelial vasodilator dysfunction.[3]

Features and Benefits

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Preparation Note

Spironolactone yields clear, faint yellow solution in chloroform at 50 mg/ml.

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Informacja o środkach bezpieczeństwa

• pictograms: GHS08
• signalword: Danger
• hcodes: H351,H360FD,H373
• pcodes: P202 - P260 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Carc. 2 - Repr. 1B - STOT RE 2
• Klasa składowania: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type P2 (EN 143) respirator cartridges