This product has not been tested for use in cell culture. The solubility is tested at 50 mg/mL in a 95:5, v/v mixture of Chloroform and Methanol. The powder is insoluble in aqueous solutions such as cell culture medium. Please see the link below to review additional information available in the product datasheet:
https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/402/405/p7769pis.pdf
P7769
1,2-Diacyl-sn-glycero-3-phospho-L-serine
from bovine brain, ≥97% (TLC), amorphous powder, structural phospholipid
Synonim(y):
3-sn-Phosphatidyl-L-serine, L-α-Phosphatidyl-L-serine, PS, Phosphatidylserine
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Wybierz wielkość
5 MG
307,00 zł
25 MG
1120,00 zł
100 MG
3410,00 zł
307,00 zł
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Informacje o tej pozycji
UNSPSC Code:
12352200
NACRES:
NA.77
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Pozwól nam pomócNazwa produktu
1,2-Diacyl-sn-glycero-3-phospho-L-serine, ≥97% (TLC), from bovine brain, amorphous powder
biological source
bovine brain
assay
≥97% (TLC)
form
amorphous powder
storage temp.
−20°C
Quality Level
Powiązane kategorie
Application
1,2-Diacyl-sn-glycero-3-phospho-L-serine has been used:
- as a lipid standard in time-of-flight secondary ion mass spectrometry (ToF-SIMS) spectral fingerprints[1]
- as a reference standard in thin layer chromatography (TLC) for quantifying lipids from astrocyte-conditioned media (ACM) treated fibroblasts[2]
- as a component of large unilamellar vesicles for annexin A2 aggregation studies[3]
Biochem/physiol Actions
1,2-Diacyl-sn-glycero-3-phospho-L-serine or phosphatidylserine (PS) is a structurally diverse acidic phospholipid having fatty acid ester at the glycerol sn positions. Bovine brain cortex based PS is a potent brain nutrient. It favors neurotransmission and may improve memory in dementia.[4] PS is also the major membrane phospholipid associated with the nuclear membrane, myelin, endoplasmic reticulum, Golgi and mitochondria.[5] The synthesis of PS is catalyzed by phosphatidylserine synthase 1 from L-serine and CDP-diacylglycerol in the mitochondria-associated membrane (MAM) domains of the endoplasmic reticulum.[6] PS is externalized during phagocytosis and is dysregulated in tumors making it a potential marker for therapeutic targeting.[7]
A slowly metabolized structural phospholipid found mainly in gray matter.
Features and Benefits
This compound is featured on the Phospholipase D and PKC pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Disclaimer
Solutions exposed to room temperature will decompose about 0.5% per day.
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Klasa składowania
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
ApoE4 upregulates the activity of mitochondria-associated ER membranes
Tambini MD, et al.
EMBO Reports, 17(1), 27-36 (2016)
Characterization of freeze-fractured epithelial plasma membranes on nanometer scale with ToF-SIMS
Draude F, et al.
Analytical and Bioanalytical Chemistry, 407(8), 2203-2211 (2015)
Comparison of molecular species of various transphosphatidylated phosphatidylserine (PS) with bovine cortex PS by mass spectrometry
Chen S and Li KW
Chemistry and Physics of Lipids, 152(1), 46-56 (2008)
Phosphatidylserine is a global immunosuppressive signal in efferocytosis, infectious disease, and cancer
Birge RB, et al.
Cell Death and Differentiation, 23(6), 962-962 (2016)
Formation and function of phosphatidylserine and phosphatidylethanolamine in mammalian cells
Vance JE and Tasseva G
Biochimica et biophysica acta. General subjects, 1831(3), 543-554 (2013)
Produkty
Discover Bioactive Small Molecules for Lipid Signaling Research
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Product Information Sheet
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Hi I am going to purchase phsophatidylserine (P7769). What is the solvent for this? Is it better to use powder one or solution one for the cell assay?
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