P7679
Monoclonal Anti-Platelet-Derived Growth Factor Receptor β antibody produced in mouse
clone PDGFR-B2, ascites fluid
Synonim(y):
Anti-PDGF Rβ
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Informacje o tej pozycji
UNSPSC Code:
51111800
MDL number:
Pomoc techniczna
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Pozwól nam pomócbiological source
mouse
conjugate
unconjugated
antibody form
ascites fluid
clone
PDGFR-B2, monoclonal
contains
15 mM sodium azide
species reactivity
human, pig
technique(s)
immunohistochemistry (frozen sections): suitable, immunoprecipitation (IP): suitable, microarray: suitable, western blot: 1:100 using denatured, non-reduced porcine uterus extract
isotype
IgG2b
shipped in
dry ice
storage temp.
−20°C
Gene Information
human ... PDGFRB(5159)
Immunogen
PDGF β-receptor from pig uterus.
Biochem/physiol Actions
The antibody recognizes human and pig PDGF Rβ, but not mouse or rat. It can be used for immunoperoxidase and immunofluorescence staining of unfixed or acetone-fixed frozen tissue. The antibody induces clustering and down-regulation of PDGF Rβ. The antibody does not cross react with PDGF Rα.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Powiązane treści
Datasheet
C Reuterdahl et al.
Laboratory investigation; a journal of technical methods and pathology, 64(3), 321-329 (1991-03-01)
Platelet-derived growth factor (PDGF) beta-receptor expression in normal and rheumatoid synovia was investigated by double immunofluorescence staining of frozen sections and by in situ hybridization. In the inflamed synovia, PDGF beta-receptor mRNA was present in vascular cells, as well as
P Höddelius et al.
Bioscience reports, 20(2), 119-127 (2000-08-31)
When the receptors for platelet-derived growth factor (PDGF) are activated they aggregate, become tyrosine-phosphorylated and elicit a cascade of down-stream signals, including mobilization of Ca2+ from intra- and extracellular stores. Receptor mobility in the plane of the membrane is a
A Sorkin et al.
The Journal of cell biology, 112(3), 469-478 (1991-02-01)
The complementary DNAs for wildtype and tyrosine kinase-inactivated (K634A) forms of the PDGF beta-receptor were expressed in porcine aortic endothelial cells. We examined the internalization and degradation of ligands and receptors after exposure of receptor expressing cells to PDGF-BB, which