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P6993

Protein Phosphatase 2A₁ bovine

Name: Protein Phosphatase 2A<SUB>1</SUB> bovine
Brand: SIGMA
Price: 3610 PLN

≥1500 units/mg protein

Synonim(y):

PPA2A₁

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Gabaryty przesyłki	SKU	Dostępność	Cena netto
1 vial		Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności	3610,00 zł

Informacje o tej pozycji

UNSPSC Code:

12352204

NACRES:

NA.54

MDL number:

MFCD00241719

Specific activity:

≥1500 units/mg protein

Assay:

≥90% (SDS-PAGE)

Biological source:

bovine

3610,00 zł

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Właściwości

biological source

bovine

Quality Segment

200

assay

≥90% (SDS-PAGE)

form

solution

specific activity

≥1500 units/mg protein

mol wt

192 kDa

packaging

vial of 1 μg

shipped in

dry ice

storage temp.

−70°C

Opis

General description

Protein Phosphatase 2A1 (PP2A1) belongs to the PP2A family and comprises trimeric A, B and C subunits.[1] PPA2 enzymes are serine/threonine phosphatases[2] and exist as several isoforms.[3]

Application

Protein phosphatase 2A₁ has been used to treat human fibroblast cells prior to western blot analysis[4].

Biochem/physiol Actions

Protein Phosphatase 2A is a cytoplasmic protein, which colocalizes with microtubule proteins and is involved in the dephosphorylation of the tau protein and oncoprotein 18. Protein Phosphatase 2A1 (PP2A1) binds to polymerized microtubule proteins and may be targeted by tubulin in modulating phosphatase activity.[1] PP2A1 is implicated as a growth suppressor and is associated with dysregulation in cancer.[2] It also regulates cell cycle, RNA splicing differentiation, and signal transduction.[2] PP2A dysfunction is correlated to the tau protein deregulation in Alzheimer′s disease pathophysiology.[3] Protein Phosphatase 2A1 is a divalent cation-dependent protein serine/threonine phosphatase implicated as a growth suppressor and is associated with dysregulation in cancer.

Physical form

Solution in 50 mM Tris-HCl, pH 7.0, containing 14 mM 2-mercaptoethanol, 1 mM benzamidine, 0.1 mM PMSF, 1 mM EDTA, and 50% glycerol

Other Notes

One unit will release 1.0 nanomole of phosphate from ³²P-labeled phosphorylase A per minute at pH 7.0 at 30 °C.

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Ta pozycja	P1868	P1743	P7937
Sigma-Aldrich P6993 Protein Phosphatase 2A₁ bovine	Sigma-Aldrich P1868 Protein Phosphatase 2A₂ from bovine kidney	Sigma-Aldrich P1743 Protein Phosphatase 2C from bovine brain	Sigma-Aldrich P7937 Protein Phosphatase-1 Catalytic Subunit, α-Isoform from rabbit
biological source bovine	biological source bovine kidney	biological source bovine brain	biological source rabbit
assay ≥90% (SDS-PAGE)	assay -	assay >90% (SDS-GE)	assay ≥80% (GE)
specific activity ≥1500 units/mg protein	specific activity ~2.0 U/vial	specific activity ~1000 units/mg protein	specific activity 5,000-15,000 units/mg protein
form solution	form buffered aqueous glycerol solution	form buffered aqueous glycerol solution	form lyophilized powder
shipped in dry ice	shipped in dry ice	shipped in dry ice	shipped in -
mol wt 192 kDa	mol wt dimer 101 kDa (65 kDa and 36 kDa)	mol wt 42-45 kDa	mol wt 37.5 kDa