O0391

Olopatadine hydrochloride

≥98% (HPLC)

• Synonim(y): (11Z)-11-[3-(Dimethylamino)propylidene]-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid hydrochloride, AL-4943A, KW-4679, Opatanol, Patanol
• Wzór empiryczny (zapis Hilla): C₂₁H₂₃NO₃·HCl
• Numer CAS: 140462-76-6
• Masa cząsteczkowa: 373.87
• NACRES: NA.77
• PubChem Substance ID: 329818840
• UNSPSC Code: 12352200
• MDL number: MFCD00875716
• Assay: ≥98% (HPLC)
• Form: solid

Właściwości

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: solid
• solubility: H₂O: ≥20 mg/mL
• storage temp.: room temp
• SMILES string: Cl.CN(C)CC\C=C1\c2ccccc2COc3ccc(CC(O)=O)cc13
• InChI: 1S/C21H23NO3.ClH/c1-22(2)11-5-8-18-17-7-4-3-6-16(17)14-25-20-10-9-15(12-19(18)20)13-21(23)24;/h3-4,6-10,12H,5,11,13-14H2,1-2H3,(H,23,24);1H/b18-8-;
• InChI key: HVRLZEKDTUEKQH-NOILCQHBSA-N
• Gene Information: human ... HRH1(3269)

Opis

Biochem/physiol Actions

Olopatadine is a dual acting histamine H1-receptor antagonist and mast cell stabilizer.

Olopatadine is a histamine H1 receptor antagonist and mast cell stabilizer. The low level of occupancy H1 receptors in the brain explains the low sedation effect of olopatidine. It is believed that olopatidine is a substrate for P-glycoprotein, which limits its brain penetration.

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Informacja o środkach bezpieczeństwa

• pictograms: GHS06,GHS09
• signalword: Danger
• hcodes: H301,H400
• pcodes: P273 - P301 + P310 + P330
• Hazard Classifications: Acute Tox. 3 Oral - Aquatic Acute 1
• Klasa składowania: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable