N7032

NFAT Inhibitor

>96% (HPLC), solid

• Synonim(y): VIVIT
• Wzór empiryczny (zapis Hilla): C₇₅H₁₁₈N₂₀O₂₂S
• Numer CAS: 249537-73-3
• Masa cząsteczkowa: 1683.93
• UNSPSC Code: 12352202
• NACRES: NA.26
• MDL number: MFCD02683959

Właściwości

• Quality Level: 300
• assay: >96% (HPLC)
• form: solid
• storage temp.: −20°C
• SMILES string: S(CC[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(=O)N1[C@@H](CCC1)C(=O)N[C@@H](Cc5nc[nH]c5)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@H](CC)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@H](CC)C)C(=O)N[C@@H]([C@H](O)C)C(=O)NCC(=O)N3[C@@H](CCC3)C(=O)N[C@@H](Cc4nc[nH]c
• InChI: 1S/C75H118N20O22S/c1-12-39(7)59(90-70(111)57(37(3)4)88-68(109)52-19-16-27-95(52)74(115)49(30-44-32-78-36-82-44)87-67(108)51-18-15-26-94(51)53(97)33-79-62(103)41(9)83-63(104)45(76)24-28-118-11)72(113)89-58(38(5)6)71(112)91-60(40(8)13-2)73(114)92-61(42(10)96)69(110)80-34-54(98)93-25-14-17-50(93)66(107)86-48(29-43-31-77-35-81-43)65(106)84-46(20-22-55(99)100)64(105)85-47(75(116)117)21-23-56(101)102/h31-32,35-42,45-52,57-61,96H,12-30,33-34,76H2,1-11H3,(H,77,81)(H,78,82)(H,79,103)(H,80,110)(H,83,104)(H,84,106)(H,85,105)(H,86,107)(H,87,108)(H,88,109)(H,89,113)(H,90,111)(H,91,112)(H,92,114)(H,99,100)(H,101,102)(H,116,117)/t39-,40-,41-,42+,45-,46-,47-,48-,49-,50-,51-,52-,57-,58-,59-,60-,61-/m0/s1
• InChI key: QPMHUXBSHGAVGD-MCDIZDEASA-N
• Gene Information: human ... NFATC1(4772), NFATC2(4773) ; mouse ... Nfatc1(18018), Nfatc2(18019)

Opis

Application

NFAT Inhibitor, VIVIT has been used to study the signaling pathways involved in controlling inhibitory molecules and subsequent onset of T-cell impairment.[1]

NFAT inhibitor has been as an inhibitor of nuclear factor of activated T cells.

Biochem/physiol Actions

High-affinity calcineurin-binding peptide that inhibits NFAT (Nuclear Factor of Activated T cells) activation and NFAT-dependent expression of endogenous cytokine genes in T cells.

Inhibits NFAT (Nuclear Factor of Activated T cells) activation and NFAT-dependent expression of endogenous cytokine genes in T cells.

Nuclear factor of activated T cells (NFAT) participates in the activity and growth of immune and non-immune cells.[2]

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)