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M9695

Matrix Metalloproteinase-12, Catalytic Domain human

recombinant, expressed in E. coli, ≥95% (SDS-PAGE), buffered aqueous glycerol solution

Synonim(y):

MMP-12, Macrophage Elastase

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Gabaryty przesyłkiSKUDostępnośćCena netto
10 μg
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2790,00 zł

Informacje o tej pozycji

UNSPSC Code:
12352202
NACRES:
NA.32
MDL number:
MFCD02688053

2790,00 zł

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recombinant

expressed in E. coli

Quality Level

200

assay

≥95% (SDS-PAGE)

form

buffered aqueous glycerol solution

mol wt

calculated mol wt 20.3 kDa

UniProt accession no.

P39900

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... MMP12(4321)

General description

Matrix metalloproteinase-12 (MMP-12) is also called as macrophage metalloelastase and is secreted by inflammatory macrophages. It is synthesized as a zymogen and then activated by cleaving the propeptide domain. The MMP-12 gene is localized on chromosome 11.[1][2]

Biochem/physiol Actions

MMP-12 degrades general matrix components and may have a role in processes such as host defense, cell proliferation, and protein turnover as well as tissue remodeling.
Matrix metalloproteinase-12 (MMP-12) breaks down proteoglycans, collagen type IV and laminin. Its main substrate is elastin.[2]

Physical form

Solution in 50 mM Tris, 5 mM calcium chloride, 500 mM sodium chloride, 20 μM zinc chloride, 0.5% Brij® L23, and 30% glycerol, pH 9.5.

Other Notes

One unit equals 100 pmol/min at 37 °C using the colorimetric thiopeptolide Ac-Pro-Leu-Gly-S-Leu-Leu-Gly-OEt as substrate.

Legal Information

Brij is a registered trademark of Croda International PLC
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Ta pozycja
M9445M9070M9195
Matrix Metalloproteinase-12, Catalytic Domain human recombinant, expressed in E. coli, ≥95% (SDS-PAGE), buffered aqueous glycerol solution

Sigma-Aldrich

M9695

Matrix Metalloproteinase-12, Catalytic Domain human

Matrix Metalloproteinase-2 from mouse recombinant, expressed in NSO cells, >95% (SDS-PAGE), buffered aqueous glycerol solution

Sigma-Aldrich

M9445

Matrix Metalloproteinase-2 from mouse

Matrix Metalloproteinase-2 human >90% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder

Sigma-Aldrich

M9070

Matrix Metalloproteinase-2 human

Matrix Metalloproteinase-1 human recombinant, expressed in NSO cells, >95% (SDS-PAGE), buffered aqueous solution

Sigma-Aldrich

M9195

Matrix Metalloproteinase-1 human

recombinant

expressed in E. coli

recombinant

expressed in NSO cells

recombinant

expressed in NSO cells

recombinant

expressed in NSO cells

assay

≥95% (SDS-PAGE)

assay

>95% (SDS-PAGE)

assay

>90% (SDS-PAGE)

assay

>95% (SDS-PAGE)

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

form

buffered aqueous glycerol solution

form

buffered aqueous glycerol solution

form

lyophilized powder

form

buffered aqueous solution

UniProt accession no.

P39900

UniProt accession no.

P33434, P33436

UniProt accession no.

P08253

UniProt accession no.

P03956

mol wt

calculated mol wt 20.3 kDa

mol wt

apparent mol wt ~72 kDa

mol wt

apparent mol wt ~69 kDa

mol wt

apparent mol wt 52-55 kDa

hcodes

H412

Hazard Classifications

Aquatic Chronic 3

Klasa składowania

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Gloves, multi-purpose combination respirator cartridge (US)

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Certyfikaty analizy (CoA)

Lot/Batch Number
0000353060
0000349687
0000353060
0000349687
SLCR3933

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Odwiedź Bibliotekę dokumentów

Yi Song et al.
BMC cardiovascular disorders, 13, 34-34 (2013-05-07)
Aortic dissection(AD) is an acute process of large blood vessels characterized by dangerous pathogenic conditions and high disability and high mortality. The pathogenesis of AD remains debated. Matrix metalloproteinase-12 (MMP-12) participates in many pathological processes such as abdominal aortic aneurysm
Matthew Traylor et al.
PLoS genetics, 10(7), e1004469-e1004469 (2014-08-01)
Genome-wide association studies (GWAS) have begun to identify the common genetic component to ischaemic stroke (IS). However, IS has considerable phenotypic heterogeneity. Where clinical covariates explain a large fraction of disease risk, covariate informed designs can increase power to detect
S D Shapiro
Current opinion in cell biology, 10(5), 602-608 (1998-11-18)
Targeted mutagenesis has allowed investigators to perform controlled experiments in mammals and determine the contribution of individual proteins to physiologic and pathologic processes. Recent lessons learned from matrix metalloproteinase gene targeted mice and other in vivo observations have given new
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SKUNUMER GTIN
M9695-10UG04061838031945

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