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M8131
α-Methyl-L-tyrosine
≥98% (TLC)
Synonim(y):
L-2-Methyl-3-(4-hydroxyphenyl)alanine, L-AMPT
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Informacje o tej pozycji
Wzór empiryczny (zapis Hilla):
C10H13NO3
Numer CAS:
Masa cząsteczkowa:
195.22
UNSPSC Code:
12352200
NACRES:
NA.32
PubChem Substance ID:
EC Number:
211-599-5
Beilstein/REAXYS Number:
2368400
MDL number:
assay
≥98% (TLC)
form
powder
storage temp.
−20°C
SMILES string
C[C@](N)(Cc1ccc(O)cc1)C(O)=O
InChI
1S/C10H13NO3/c1-10(11,9(13)14)6-7-2-4-8(12)5-3-7/h2-5,12H,6,11H2,1H3,(H,13,14)/t10-/m0/s1
InChI key
NHTGHBARYWONDQ-JTQLQIEISA-N
Gene Information
human ... TH(7054)
Application
α-Methyl-L-tyrosine is used to determine whether Fe2/ methamphetamine (METH) -induced cell death is dependent on cytosolic dopamine and iron mediated oxidative stress.
α-Methyl-L-tyrosine has been used as an inhibitor tyrosine hydroxylase:
- to test its effect during acute stress in zebrafish[1]
- in cannabinoid receptor type-1 (CB1) knockout and wild type mice, to test its effect on norepinephrine turnover[2]
- to test catecholamines depletion on stress in rat spleen samples[3]
- to block dopamine synthesis in dopaminergic neurons[4]
Biochem/physiol Actions
α-Methyl-L-tyrosine (L-AMPT) acts as a competitive inhibitor of tyrosine hydroxylase and inhibits the conversion of tyrosine to L-DOPA and eventually lowers dopamine synthesis in cytosol. AMPT at low concentrations can be used as a potent therapeutic for refractory dystonia or dyskinesia. It also helps in decreasing catecholamine concentration in pheochromocytoma patients.
Tyrosine hydroxylase inhibitor.
Other Notes
Active isomer
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Klasa składowania
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Renan Idalencio et al.
General and comparative endocrinology, 252, 236-238 (2017-07-19)
In this article, we show that the tyrosine hydroxylase inhibitor α-Methyl-l-tyrosine (AMPT) decreased the responsiveness of the zebrafish stress axis to an acute stressful challenge. These effects were specific for responses to stimulation, since unstimulated (basal) cortisol levels were not
Sergio Ortiz-Padilla et al.
Neuropharmacology, 166, 107920-107920 (2019-12-25)
Dopaminergic neurons have the ability to release Dopamine from their axons as well as from their soma and dendrites. This somatodendritically-released Dopamine induces an autoinhibition of Dopaminergic neurons mediated by D2 autoreceptors, and the stimulation of neighbor GABAergic neurons mediated
Low dose alpha-methyl-para-tyrosine (AMPT) in the treatment of dystonia and dyskinesia.
Ankenman R and Salvatore MF
The Journal of Neuropsychiatry and Clinical Neurosciences, 19(1), 65-69 (2007)
Numer pozycji handlu globalnego
| SKU | NUMER GTIN |
|---|---|
| M8131-250MG | 04061834062813 |
| M8131-5G | 04061833630907 |
| M8131-1G | 04061834062806 |
| M8131-100MG | 04061833272978 |