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Merck

LO3300

Sigma-Aldrich

LOPAC®1280 (International Version)

Synonim(y):

Library of Pharmacologically Active Compounds

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About This Item

Kod UNSPSC:
41106609
NACRES:
NA.77

Postać

liquid

Poziom jakości

Warunki transportu

dry ice

temp. przechowywania

−20°C

Opis ogólny

Compounds are arranged in 96-well format in 16 racks of 80, one compound per well (250 μl at 10 mM in DMSO in archival storage racks).

Zastosowanie

LOPAC®1280 (International Version) has been used to screen chemical inhibitors with dephosphorylation activity. It has also been used in MyoScreen myotubes to screen for muscle regeneration molecules.

Cechy i korzyści

Collection of approximately 1,280 pharmacologically active Sigma compounds.
Includes the latest, drug-like molecules in the fields of Cell Signaling & Neuroscience:

  • Apotosis
  • G Proteins & Cyclic Nucleotides
  • Gene Regulation & Expression
  • Ion Channels
  • Lipid Signaling
  • Multi-drug Resistance
  • Neurotransmission
  • Phosphorylation
SDFile provided to construct a database containing:

  • Structure
  • Primary Name
  • Secondary Name
  • Pharmacological Activity
  • Sigma-RBI Product Number (for easy re-order)
  • Rack Position

Inne uwagi

For sale outside of the U.S. only. U.S. customers should refer to Product Code LO1280.

Informacje prawne

LOPAC is a registered trademark of Merck KGaA, Darmstadt, Germany
This page may contain text that has been machine translated.

Hasło ostrzegawcze

Danger

Klasyfikacja zagrożeń

Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1A - Eye Dam. 1 - Lact. - Muta. 1B - Repr. 1A - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1 - STOT RE 2 - STOT SE 2

Kod klasy składowania

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Temperatura zapłonu (°F)

188.6 °F - closed cup

Temperatura zapłonu (°C)

87 °C - closed cup


Certyfikaty analizy (CoA)

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Odwiedź Bibliotekę dokumentów

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Temperature-sensitive substrate and product binding underlie temperature-compensated phosphorylation in the clock
Shinohara Y, et al.
Molecular Cell, 67(5), 783-798 (2017)
Nicolas Wyhs et al.
Journal of biomolecular screening, 19(7), 1060-1069 (2014-03-13)
Methylated DNA binding proteins such as Methyl-CpG Binding Domain Protein 2 (MBD2) can transduce DNA methylation alterations into a repressive signal by recruiting transcriptional co-repressor complexes. Interfering with MBD2 could lead to reactivation of tumor suppressor genes and therefore represents
John S Lazo et al.
Molecular pharmacology, 72(1), 1-7 (2007-04-05)
Small molecules are powerful pharmacological tools to dissect biological events. There is now considerable interest in expanding efforts to identify and use small molecules targeting proteins encoded in the genomes of humans and pathogenic organisms. Integration of the principles of
Jayme L Dahlin et al.
PloS one, 8(11), e78877-e78877 (2013-11-22)
The lysine acetyltransferase (KAT) Rtt109 forms a complex with Vps75 and catalyzes the acetylation of histone H3 lysine 56 (H3K56ac) in the Asf1-H3-H4 complex. Rtt109 and H3K56ac are vital for replication-coupled nucleosome assembly and genotoxic resistance in yeast and pathogenic
MyoScreen, a High-Throughput Phenotypic Screening Platform Enabling Muscle Drug Discovery
Young J, et al.
SLAS discovery, 23(8), 790-806 (2018)

Produkty

Explore compound library screening options with our Pharmacologically Active Compounds portfolio.

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