J4455

JSH-23

≥98% (HPLC), NF-kB nuclear translocation inhibitor, solid

• Synonim(y): 4-methyl-N1-(3-phenylpropyl)-1,2-benzenediamine
• Wzór empiryczny (zapis Hilla): C₁₆H₂₀N₂
• Numer CAS: 749886-87-1
• Masa cząsteczkowa: 240.34
• UNSPSC Code: 51111800
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: solid
• Storage condition: protect from light

Właściwości

• Nazwa produktu: JSH-23, ≥98% (HPLC), solid
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: solid
• storage condition: protect from light
• color: off-white to gray-pink
• solubility: DMSO: >10 mg/mL
• shipped in: wet ice
• storage temp.: −20°C
• SMILES string: N(CCCc2ccccc2)c1c(cc(cc1)C)N
• InChI: 1S/C16H20N2/c1-13-9-10-16(15(17)12-13)18-11-5-8-14-6-3-2-4-7-14/h2-4,6-7,9-10,12,18H,5,8,11,17H2,1H3
• InChI key: YMFNPBSZFWXMAD-UHFFFAOYSA-N

Opis

Application

JSH-23 has been used as a nuclear factor κB (NF-κB) p65 inhibitor.[1][2]

Biochem/physiol Actions

JSH-23 is an inhibitor of NF-kB nuclear translocation.

JSH-23 is an inhibitor of NF-kB nuclear translocation. It inhibits LPS and cytokine-induced nuclear translocation of the p65 subunit of NF-kB as analyzed by EMSA and western blot. The compound displays modest potency (IC50 7.1 uM in RAW 264.7), but has the unique property that it does not affect IkB degradation or recovery. The compound dose dependently inhibits LPS induced expression of cytokines, COX2 and iNOS, and presumably binds to, or interferes with the NLS of p65.

Other Notes

Light and air sensitive.

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• pictograms: GHS07
• signalword: Warning
• hcodes: H302,H317
• pcodes: P261 - P264 - P272 - P280 - P301 + P312 - P302 + P352
• Hazard Classifications: Acute Tox. 4 Oral - Skin Sens. 1B