I4161

IL-2 mouse

Name: IL-2 mouse
Brand: SIGMA
Price: 1320 PLN

≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Synonim(y):

IL-2, Interleukin-2, T-cell growth factor, mIL-2

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Wybierz wielkość

20 μG

1320,00 zł

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Informacje o tej pozycji

UNSPSC Code:

12352202

NACRES:

NA.77

MDL number:

MFCD00164816

Biological source:

mouse

Recombinant:

expressed in E. coli

Assay:

≥97% (SDS-PAGE)

Form:

lyophilized powder

Mol wt:

17.2 kDa

Impurities:

≤0.200ng/ml

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Nazwa produktu

Interleukin-2 from mouse, IL-2, recombinant, expressed in E. coli, carrier free

biological source

mouse

Quality Level

200

recombinant

expressed in E. coli

assay

≥97% (SDS-PAGE)

form

lyophilized powder

potency

≤0.2 ng/mL ED₅₀

quality

endotoxin tested

mol wt

17.2 kDa

packaging

pkg of 5X20 μg, pkg of 20 μg

technique(s)

cell culture | mammalian: suitable

impurities

≤0.200ng/ml

color

white

UniProt accession no.

P04351

shipped in

dry ice

storage temp.

−20°C

Gene Information

mouse ... Il2(16183)

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Ta pozycja	I0523	I3019	I7908
Sigma-Aldrich I4161 Interleukin-2 from mouse	Sigma-Aldrich I0523 Interleukin-2 from mouse	Sigma-Aldrich I3019 Interleukin-10 from mouse	I7908 Interleukin-2 human
technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable
biological source mouse	biological source mouse	biological source mouse	biological source human
assay ≥97% (SDS-PAGE)	assay ≥97% (SDS-PAGE)	assay >97% (SDS-PAGE)	assay ≥98% (SDS-PAGE and HPLC)
recombinant expressed in E. coli	recombinant expressed in E. coli	recombinant expressed in E. coli	recombinant expressed in Pichia pastoris
Quality Level 200	Quality Level 200	Quality Level 200	Quality Level 200
form lyophilized powder	form lyophilized powder	form lyophilized powder	form lyophilized powder

Biochem/physiol Actions

Interleukin-2 (IL-2) is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation. Recombinant human IL-2 is a 15.5 kDa protein, containing 134 amino acid residues including one intrachain disulfide bond.

Physical form

Lyophilized with no additives.

Preparation Note

Centrifuge vial prior to opening. Reconstitute the contents of the vial in water to a concentration range of 0.1-1.0 mg/mL.

IL-2 is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation. IL-2/IL-2R signaling is required for T-cell proliferation and other fundamental functions which are essential for the immune response. IL-2 stimulates growth and differentiation of B-cells, NK cells, lymphokine activated killer cells, monocytes, macrophages and oligodendrocytes. Recombinant human IL-2 is a 15.5 kDa protein, containing 134 amino acid residues including one intrachain disulfide bond.

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pictograms

GHS07

signalword

Warning

hcodes

H319,H335

pcodes

P261 - P264 - P271 - P280 - P304 + P340 + P312 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Klasa składowania

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Lot/Batch Number

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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Attenuation of early atherosclerotic lesions by immunotolerance with β2 glycoprotein I and the immunomodulatory effectors interleukin 2 and 10 in a murine model.

Joaquin De Haro et al.

Journal of vascular surgery, 62(6), 1625-1631 (2014-07-22)

This study assessed the effect of cellular and humoral autoimmune response inhibition after immunization with β2-glycoprotein I (β2-GPI) and the effect of immunomodulation with interleukin (IL)-2 and IL-10 in the development of early atherosclerotic vascular lesion in a murine model.

Human Epidermal Growth Factor Receptor 2 (HER2) -Specific Chimeric Antigen Receptor-Modified T Cells for the Immunotherapy of HER2-Positive Sarcoma.

Nabil Ahmed et al.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 33(15), 1688-1696 (2015-03-25)

The outcome for patients with metastatic or recurrent sarcoma remains poor. Adoptive therapy with tumor-directed T cells is an attractive therapeutic option but has never been evaluated in sarcoma. We conducted a phase I/II clinical study in which patients with

Thymic B cells promote thymus-derived regulatory T cell development and proliferation.

Fang-Ting Lu et al.

Journal of autoimmunity, 61, 62-72 (2015-06-15)

Thymic CD4(+) FoxP3(+) regulatory T (Treg) cells are critical for the development of immunological tolerance and immune homeostasis and requires contributions of both thymic dendritic and epithelial cells. Although B cells have been reported to be present within the thymus

A potent combination microbicide that targets SHIV-RT, HSV-2 and HPV.

Larisa Kizima et al.

PloS one, 9(4), e94547-e94547 (2014-04-18)

Prevalent infection with human herpes simplex 2 (HSV-2) or human papillomavirus (HPV) is associated with increased human immunodeficiency virus (HIV) acquisition. Microbicides that target HIV as well as these sexually transmitted infections (STIs) may more effectively limit HIV incidence. Previously

NAD+ protects against EAE by regulating CD4+ T-cell differentiation.

Stefan G Tullius et al.

Nature communications, 5, 5101-5101 (2014-10-08)

CD4(+) T cells are involved in the development of autoimmunity, including multiple sclerosis (MS). Here we show that nicotinamide adenine dinucleotide (NAD(+)) blocks experimental autoimmune encephalomyelitis (EAE), a mouse model of MS, by inducing immune homeostasis through CD4(+)IFNγ(+)IL-10(+) T cells

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Data Sheet - I4161

Instructions

Numer pozycji handlu globalnego

SKU	NUMER GTIN
I4161-20UG	04061833856666
I4161-5X20UG	04061833856673

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