Human IgA exists in 2 forms. It is a monomer in the serum and a dimer in mucosal secretory tissues [secretory IgA (sIgA)]. Secretory IgA is a complex comprising two IgA monomers, a connecting J chain, and a secretory component.
I4036
IgA from human serum
reagent grade, ≥95% (HPLC), buffered aqueous solution
Synonim(y):
Human IgA
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Informacje o tej pozycji
NACRES:
NA.41
UNSPSC Code:
12352203
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Pozwól nam pomócconjugate
unconjugated
grade
reagent grade
assay
≥95% (HPLC)
form
buffered aqueous solution
storage temp.
−20°C
Quality Level
1 of 4
Ta pozycja | I2511 | 401098 | I8260 |
|---|---|---|---|
| assay ≥95% (HPLC) | assay ≥95% (HPLC) | assay ≥95% (SDS-PAGE) | assay ~95% (HPLC) |
| form buffered aqueous solution | form buffered aqueous solution | form liquid | form buffered aqueous solution |
| Quality Level 300 | Quality Level 300 | Quality Level 200 | Quality Level 300 |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. 2-8°C |
| conjugate unconjugated | conjugate unconjugated | conjugate - | conjugate unconjugated |
| grade reagent grade | grade reagent grade | grade - | grade reagent grade |
General description
IgA is one of the most abundant antibody isotypes produced in the body. It is mainly secreted by plasma cells located in the lamina propria. There are two subtypes of IgA, IgA1 and IgA2 present primarily in the airways and colon, respectively.
Application
IgA from human serum has been used in enzyme-linked immunosorbent assay (ELISA) for anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-spike-receptor binding domain (RBD) antibody detection in blood samples.
Purified human IgA may be used to study its physiological and biological effects on processes such as inflammation, pathogen elimination, regulation of antibody-dependent-cell-mediated cytotoxicity (ADCC), modulation of phagocytosis, degranulation of eosinophils and basophils and modulation of respiratory burst activity.
Biochem/physiol Actions
IgA aids in inducing a defense mechanism against various viral pathogens such as rotavirus, poliovirus, influenza virus, and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It regulates excessive immune responses in inflammatory diseases. IgA also has the potential to trigger neutrophil recruitment for cell killing.
Physical form
Solution in 0.01 M Phosphate Buffer saline, pH 7.4, containing 15 mM sodium azide as a preservative.
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Klasa składowania
12 - Non Combustible Liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Andrea Reboldi et al.
Science (New York, N.Y.), 352(6287), aaf4822-aaf4822 (2016-05-14)
Immunoglobulin A (IgA) induction primarily occurs in intestinal Peyer's patches (PPs). However, the cellular interactions necessary for IgA class switching are poorly defined. Here we show that in mice, activated B cells use the chemokine receptor CCR6 to access the
Rafael D Melani et al.
medRxiv : the preprint server for health sciences (2021-07-17)
Methods of antibody detection are used to assess exposure or immunity to a pathogen. Here, we present Ig-MS , a novel serological readout that captures the immunoglobulin (Ig) repertoire at molecular resolution, including entire variable regions in Ig light and
Isabella Quinti et al.
Frontiers in cellular and infection microbiology, 11, 655896-655896 (2021-04-24)
A large repertoire of IgA is produced by B lymphocytes with T-independent and T-dependent mechanisms useful in defense against pathogenic microorganisms and to reduce immune activation. IgA is active against several pathogens, including rotavirus, poliovirus, influenza virus, and SARS-CoV-2. It
Development of a Duplex Serological Multiplex Assay for the Simultaneous Detection of Epstein-Barr Virus IgA and IgG Antibodies in Nasopharyngeal Carcinoma Patients.
Schieber, et al.
Cancers, 15 (2023)
Tobias Schlesinger et al.
PloS one, 15(11), e0242917-e0242917 (2020-11-25)
The viral load and tissue distribution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remain important questions. The current study investigated SARS-CoV-2 viral load, biodistribution and anti-SARS-CoV-2 antibody formation in patients suffering from severe corona virus disease 2019 (COVID-19) induced
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What is the isoform of the IgA? Is it only in its dimeric form or is it a mix of the monomer and the dimer?
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