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H7630

Sigma-Aldrich

Hyaluronic acid sodium salt from bovine vitreous humor

Synonim(y):

Poly(β-glucuronic acid-[1→3]-β-N-acetylglucosamine-[1→4]), alternating

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About This Item

Wzór liniowy:
(C14H21NaNO11)n
Numer CAS:
9067-32-7
Numer MDL:
MFCD01773053
Kod UNSPSC:
12352201
NACRES:
NA.77

pochodzenie biologiczne

bovine (vitreous humor)

Postać

powder

kolor

white

rozpuszczalność

water: ~5 g/L

temp. przechowywania

−20°C

InChI

1S/C28H44N2O23.Na/c1-5(33)29-9-18(11(35)7(3-31)47-25(9)46)49-28-17(41)15(39)20(22(53-28)24(44)45)51-26-10(30-6(2)34)19(12(36)8(4-32)48-26)50-27-16(40)13(37)14(38)21(52-27)23(42)43;/h7-22,25-28,31-32,35-41,46H,3-4H2,1-2H3,(H,29,33)(H,30,34)(H,42,43)(H,44,45);/q;+1/t7-,8-,9-,10-,11-,12-,13+,14+,15-,16-,17-,18-,19-,20+,21+,22+,25-,26+,27-,28-;/m1./s1

Klucz InChI

YWIVKILSMZOHHF-QJZPQSOGSA-N

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Zastosowanie

Hyaluronic acid sodium salt from bovine vitreous humor has been used:
  • as a component for the generation of artificial synovial fluid
  • to investigate its role in inducing oxidative stress and interleukin 8(IL-8) production in human nasal RPMI 2650 cells
  • to test its effect on B cell proliferation
  • as a substrate in neuraminidase assay of morbilliviruses virus

Działania biochem./fizjol.

High molecular mass polymer composed of repeating dimeric units of glucuronic acid and N-acetyl glucosamine which forms the core of complex proteoglycan aggregates found in extracellular matrix.
Hyaluronic acid (HA) is abundantly present in the bovine vitreous humor. It corresponds to a molecular weight of 69293.9Da and has an isoelectric pH of 5.82. Bovine HA has high levels of endotoxins and it polydisperse with DNA and RNA contaminants. The enzyme HA synthases at the plasma membrane (HASs) aids in the synthesis of circulatory HA. HA is implicated in many physiological processes including inflammation, immune regulation, adhesion, embryo development and tumor progression.

Inne uwagi

To gain a comprehensive understanding of our extensive range of Polysaccharides for your research, we encourage you to visit our Carbohydrates Category page.
This page may contain text that has been machine translated.

Kod klasy składowania

11 - Combustible Solids

Klasa zagrożenia wodnego (WGK)

WGK 2

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Środki ochrony indywidualnej

dust mask type N95 (US), Eyeshields, Gloves

Certyfikaty analizy (CoA)

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Masz już ten produkt?

Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Evaluation of hyaluronic acid in cattle: physiological variations related to age, periparturition and in clinical cases of paratuberculosis
Jolly A, et al.
Journal of Veterinary Science and Technology, 7(4), 342-346 (2016)
Sequence and structure alignment of Paramyxoviridae attachment proteins and discovery of enzymatic activity for a morbillivirus hemagglutinin.
Langedijk JP, et al.
Journal of virology, 71(8), 6155-6167 (1997)
Role of the biomolecular interactions in the structure and tribological properties of synovial fluid
Mirea DA, et al.
Tribology International, 59(4), 302-311 (2013)
Yi-Wen Lin et al.
Molecules (Basel, Switzerland), 25(19) (2020-10-01)
Osteoarthritis (OA) is the most common joint disease type and is accompanied by varying degrees of functional limitation. Both hyaluronic acid (HA) joint injections and pain relievers are efficient treatments for early-stage osteoarthritis. However, for the decomposition by hyaluronidase and
Effect of high, medium, and low molecular weight hyaluronan on inflammation and oxidative stress in an in vitro model of human nasal epithelial cells
Albano GD, et al.
Mediators of Inflammation, 2016 (2016)
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Produkty

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Glikozaminoglikany i proteoglikany

Dowiedz się więcej o glikozoaminoglikanach i proteoglikanach, w tym o strukturze glikozoaminoglikanów (GAG), różnych typach GAG i ich funkcjach.

Glycosaminoglycan Sulfation and Signaling

Glycosaminoglycans are large linear polysaccharides constructed of repeating disaccharide units.

Protokoły

Enzymatic Assay of Hyaluronidase (3.2.1.35)

To measure hyaluronidase activity, a turbidimetric determination assay is used at 600 nm. One unit of hyaluronidase activity will cause a change in absorbance of 0.330 per minute at pH 5.35 at 37 °C.

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