H3661

4′-Hydroxydiclofenac

≥98% (HPLC)

• Synonim(y): 4′-Hydroxy Diclofenac, [2-(2,6-Dichloro-4-hydroxy-phenylamino)phenyl]acetic acid
• Wzór empiryczny (zapis Hilla): C₁₄H₁₁Cl₂NO₃
• Numer CAS: 64118-84-9
• Masa cząsteczkowa: 312.15
• UNSPSC Code: 12161501
• NACRES: NA.47
• PubChem Substance ID: 24895589
• MDL number: MFCD01671980
• Beilstein/REAXYS Number: 4198042

Właściwości

• Quality Level: 200
• assay: ≥98% (HPLC)
• packaging: vial of 5 mg
• storage temp.: −20°C
• SMILES string: OC(=O)Cc1ccccc1Nc2c(Cl)cc(O)cc2Cl
• InChI: 1S/C14H11Cl2NO3/c15-10-6-9(18)7-11(16)14(10)17-12-4-2-1-3-8(12)5-13(19)20/h1-4,6-7,17-18H,5H2,(H,19,20)
• InChI key: KGVXVPRLBMWZLG-UHFFFAOYSA-N

Opis

General description

CYP2C9 metabolite of diclofenac.

4′-Hydroxydiclofenac is an important metabolite of aceclofenac, seen mainly in rats.[1] It is the important oxidative metabolite found in urine.

Application

4′-Hydroxydiclofenac has been used to investigate the effect of gentiopicroside (GE) on human cytochrome P450 enzymes in vitro. It has also been used as an enzyme marker to study its metabolic activities in different in vitro liver models.

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Informacja o środkach bezpieczeństwa

• pictograms: GHS06,GHS05,GHS09
• signalword: Danger
• hcodes: H301,H315,H318,H335,H410
• pcodes: P261 - P273 - P280 - P301 + P310 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Klasa składowania: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• ppe: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges