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F3929
Anti-Follicle-Stimulating Hormone Receptor antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
Synonim(y):
Anti-FSHR
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About This Item
Polecane produkty
pochodzenie biologiczne
rabbit
Poziom jakości
białko sprzężone
unconjugated
forma przeciwciała
affinity isolated antibody
rodzaj przeciwciała
primary antibodies
klon
polyclonal
Formularz
buffered aqueous solution
reaktywność gatunkowa
human
dostępność
not available in Japan
metody
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 7-14 μg/mL
numer dostępu UniProt
Warunki transportu
dry ice
temp. przechowywania
−20°C
docelowa modyfikacja potranslacyjna
unmodified
informacje o genach
human ... FSHR(2492)
mouse ... Fshr(14309)
rat ... Fshr(25449)
Opis ogólny
Follicle stimulating hormone receptor (FSHR) belongs to the G protein-coupled receptors family and is a glycoprotein. FSHR gene is mapped to human chromosome 2p16.3. FSHR comprises hydrophilic domain, hydrophobic membrane regions, C-terminal extracellular domain, and short intracellular domain.
Immunogen
synthetic peptide coresponding to the N-terminal extracellular domain of human follicle-stimulating hormone receptor, conjugated to KLH. The immunizing peptide has 24% identity and 29% similarity with the mouse gene.
Zastosowanie
Anti-Follicle-Stimulating Hormone Receptor antibody produced in rabbit has also been used in immunohistochemistry in ovine and reproductive tissues. It has also been used in western blotting.
Działania biochem./fizjol.
Follicle stimulating hormone receptor (FSHR) is located on Sertoli cells of the testes and the granulosa cells of ovary. The pituitary glycoprotein hormone, FSH, binds to FSHR and regulates the function of gonads and overall fertility. In Sertoli cells, FSHR-mediated cell proliferation determines the spermatogenic output. In ovarian granulosa cells, FSHR signaling mediates follicular growth and maturation of oocytes. Polymorphisms in the FSHR is implicated in premature ovarian insufficiency.
Postać fizyczna
Solution in phosphate buffered saline containing 0.1% sodium azide.
Oświadczenie o zrzeczeniu się odpowiedzialności
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Kod klasy składowania
10 - Combustible liquids
Klasa zagrożenia wodnego (WGK)
nwg
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Wenling Huang et al.
Reproductive biology and endocrinology : RB&E, 17(1), 80-80 (2019-10-21)
Whether follicle-stimulating hormone receptor (FSHR) polymorphisms are implicated in premature ovarian insufficiency (POI) remains controversial. Thus, we performed this study to explore correlation between FSHR polymorphisms and POI in human beings. Literature retrieve was conducted in PubMed, Medline, Embase and
Jitu W George et al.
Biology of reproduction, 84(1), 7-17 (2010-08-27)
Follicle-stimulating hormone (FSH), a pituitary glycoprotein hormone, is an integral component of the endocrine axis that regulates gonadal function and fertility. To transmit its signal, FSH must bind to its receptor (FSHR) located on Sertoli cells of the testis and
A T Grazul-Bilska et al.
Domestic animal endocrinology, 71, 106391-106391 (2019-11-16)
Corpus luteum (CL), a transient endocrine gland critical for reproductive cyclicity and pregnancy maintenance, is controlled by numerous regulatory factors. Although LH is widely recognized as the major regulator, other factors may also affect luteal functions. It has been demonstrated
Lingyuan Fu et al.
Journal of assisted reproduction and genetics, 30(5), 717-721 (2013-03-29)
Polycystic ovary syndrome (PCOS) is a common complex genetic endocrinopathy. It has high heritability, and twin studies indicate that it is a complex polygenic disorder. Searching for major genes of PCOS is crucial to clarify its molecular pathogenesis. A previous
Leslie L Heckert et al.
Recent progress in hormone research, 57, 129-148 (2002-05-23)
Results from experiments using mouse models suggest that the role of follicle-stimulating hormone (FSH) in spermatogenesis is the regulation of Sertoli cell proliferation and, ultimately, the size and spermatogenic capacity of the testis. The regulation of the expression of the
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