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E4389

β-Estradiol-Water Soluble

BioReagent, suitable for cell culture

Synonim(y):

Cyclodextrin-encapsulated 17β-estradiol

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Do Państwa/SKUDostępnośćCena netto
100 mg
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920,00 zł

Informacje o tej pozycji

NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352209
MDL number:
Biological source:
synthetic (organic)
Form:
powder

920,00 zł


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biological source

synthetic (organic)

Quality Segment

sterility

non-sterile

product line

BioReagent

form

powder

technique(s)

cell culture | mammalian: suitable

solubility

H2O: 25 mg/mL, clear to slightly hazy

shipped in

ambient

storage temp.

room temp

SMILES string

C[C@]12CC[C@H]3[C@@H](CCc4cc(O)ccc34)[C@@H]1CC[C@@H]2O.C[C@@H]5[C@@H](O)[C@@H]6O[C@H](CO)[C@H]5O[C@H]7O[C@H](CO)[C@@H](O[C@H]8O[C@H](CO)[C@@H](O[C@H]9O[C@H](CO)[C@@H](O[C@H]%10O[C@H](CO)[C@@H](O[C@H]%11O[C@H](CO)[C@@H](O[C@H]%12O[C@H](CO)[C@@H](O6)[C@H](O)[C@H]%12O)[C@H](O)[C@H]%11O)[C@H](O)[C@H]%10O)[C@H](O)[C@H]9O)[C@H](O)[C@H]8OCCCO)[C@H](O)[C@H]7O

InChI

1S/C46H78O35.C18H24O2/c1-12-20(55)40-68-13(5-48)32(12)75-41-26(61)25(60)37(18(10-53)69-41)81-46-39(67-4-2-3-47)31(66)38(19(11-54)74-46)80-45-30(65)24(59)36(17(9-52)73-45)79-44-29(64)23(58)35(16(8-51)72-44)78-43-28(63)22(57)34(15(7-50)71-43)77-42-27(62)21(56)33(76-40)14(6-49)70-42;1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h12-66H,2-11H2,1H3;3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t12-,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31+,32+,33-,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-;14-,15-,16+,17+,18+/m11/s1

InChI key

XMURHKLFGRLVRW-JKDYGSMVSA-N

General description

β-estradiol is a natural human estrogen. It is vital for the growth of breast and reproductive epithelia, maturation of long bones and development of secondary sexual characteristics. Estradiol is produced by immature germ cells, spermatozoa, Leydig cells and Sertoli cells.[1] β-estradiol acts as a menopausal hormones. It is involved in replacement therapy for female hypogonadism or primary ovarian failure. Reduced levels of β-estradiol are linked to heart disease and osteoporosis. Estradiol plays a critical role in proliferation, modulation of ion transport and control of apoptosis in Sertoli cells. It maintains sperm concentration, motility and morphology.[1]

Application

β-estradiol has been used:
  • to culture differentiated adipocytes
  • for estradiol treatment in rats
  • for oocyte maturation in vitro
β-Estradiol is used to study cell differentiation and transformations (tumorigenicity). This product is not recommended for use in binding assays.

Packaging

Package size based on estradiol

Other Notes

Contains 40-55 mg estradiol per gram of solid; balance 2-hydroxypropyl-β-cyclodextrin.
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Ta pozycja
E2257P7556E2758
biological source

synthetic (organic)

biological source

synthetic (organic)

biological source

synthetic (organic)

biological source

synthetic (organic)

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

product line

BioReagent

product line

BioXtra

product line

BioReagent

product line

BioReagent

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable, single cell analysis: suitable

form

powder

form

powder

form

powder

form

powder

shipped in

ambient

shipped in

ambient

shipped in

ambient

shipped in

ambient


pictograms

Health hazardEnvironment

signalword

Danger

Hazard Classifications

Aquatic Chronic 1 - Carc. 2 - Lact. - Repr. 1A

Klasa składowania

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3



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Certyfikaty analizy (CoA)

Lot/Batch Number

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Questions

1–4 of 4 Questions  
  1. what is the molecular weight of E-4389 product?

    1 answer
    1. This is a dual-component product. A single molecular weight does not apply. The molecular weight of the B-estradiol is 272.38 grams per mol, and the molecular weight of the 2-hydroxypropyl-β-cyclodextrin is 1396 grams per mol. The package size of 100 mg is in reference to the B-Estradiol. This product contains 40 - 50 mg per gram solid. The lot-specific B-estradiol content is reported in the Certificate of Analysis.

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  2. What is the storage stability of E4389, β-Estradiol - Water Soluble (25 mg/mL complex) in distilled water at 4C, -20C, or -80C?

    1 answer
    1. This product is stable for 6 months at -20°C in a non-defrosting freezer after solubilizing in distilled water. There is no stability data for this product at 4°C or -80°C.

      Helpful?

  3. How do I calculate the molarity of product E4389, β-Estradiol - Water Soluble?

    1 answer
    1. Product E4389 (β-Estradiol-Water Soluble) is a complex of β-Estradiol and cyclodextrin. Cyclodextrin is used to aid in the solubility of β-Estradiol into water. In order to prepare a molar solution of β-Estradiol you will have to base it on the β-Estradiol content in the solution and not the entire complex.

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  4. What is the Department of Transportation shipping information for this product?

    1 answer
    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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