E1257

Epidermal Growth Factor from murine submaxillary gland

lyophilized powder, BioReagent, suitable for cell culture

• Synonim(y): EGF, Epidermal cell growth factor
• Numer CAS: 62229-50-9
• Numer WE: 263-468-7
• Numer MDL: MFCD01634807
• Kod UNSPSC: 12352202
• NACRES: NA.32

Właściwości

• pochodzenie biologiczne: mouse submaxillary glands
• Poziom jakości: 200
• linia produktu: BioReagent
• Próba: ≥98% (SDS-PAGE)
• Formularz: lyophilized powder
• siła działania: 0.02-2.0 ng/mL EC₅₀
• opakowanie: pkg of 0.1 mg
• warunki przechowywania: avoid repeated freeze/thaw cycles
• metody: cell culture | mammalian: suitable
• zanieczyszczenia: endotoxin, tested
• kolor: white
• numer dostępu UniProt: P01132
• temp. przechowywania: 2-8°C
• informacje o genach: mouse ... Egf(13645)

Opis

Opis ogólny

Epidermal growth factor (EGF) is the member of EGF-like family of growth factors, that binds to EGF receptor.[1] It is majorly expressed in kidney,[2] parotid gland and salivary gland.[3]

Zastosowanie

Epidermal Growth Factor from murine submaxillary gland has been used

• in studying its effects on the development of caustic esophageal stricture in rats[4]
• for preparation of MCF-10A cell line[5]
• for the culture of primary hair follicle stem cells from arbas cashmere goat (gHFSCs) and adhesion of hair follicles (HF)[6]

Działania biochem./fizjol.

Epidermal growth factor (EGF) blocks gastric acid and pepsin secretion and increases gastrointestinal cell proliferation.[7] EGF stimulates proliferation and migration in bone marrow stromal cells (BMSC), that gives rise to osteoblasts, chondrocytes and adipocytes.[8] It functions as a strong mitogenic factor for various cultured cells. Mutations in this gene is linked to hypomagnesemia.[1] EGF plays a major role in the maintenance of hair and skin development.[9]

Postać fizyczna

Lyophilized from 0.2 μm filtered solution in ammonium acetate buffer.

Uwaga dotycząca przygotowania

Purified by gel filtration and ion-exchange chromatography.

Komentarz do analizy

The biological activity is measured in a proliferation assay using BALB/MK cells.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 2
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• Środki ochrony indywidualnej: Eyeshields, Gloves, type N95 (US)