We do not test solution stability for this product. In general, drug solutions are best prepared immediately before use. We recommend storing at -20°C in single use aliquots.
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D7693
Dynasore hydrate
≥97.5% (HPLC), powder, dynamin 1 and dynamin 2 GTPase activity inhibitor
Synonim(y):
3-Hydroxy-naphthalene-2-carboxylic acid (3,4-dihydroxy-benzylidene)-hydrazide hydrate
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| Gabaryty przesyłki | SKU | Dostępność | Cena netto |
|---|---|---|---|
| 5 mg | Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności | 708,00 zł | |
| 25 mg | Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności | 2310,00 zł |
Informacje o tej pozycji
Wzór empiryczny (zapis Hilla):
C18H14N2O4 · xH2O
Numer CAS:
Masa cząsteczkowa:
322.31 (anhydrous basis)
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
708,00 zł
Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności
Pomoc techniczna
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Pozwól nam pomócNazwa produktu
Dynasore hydrate,
form
powder
Quality Level
storage condition
protect from light
color
off-white
solubility
DMSO: ≥10 mg/mL, H2O: insoluble
storage temp.
−20°C
SMILES string
O.Oc1ccc(\C=N\NC(=O)c2cc3ccccc3cc2O)cc1O
InChI
1S/C18H14N2O4.H2O/c21-15-6-5-11(7-17(15)23)10-19-20-18(24)14-8-12-3-1-2-4-13(12)9-16(14)22;/h1-10,21-23H,(H,20,24);1H2/b19-10+;
InChI key
FKWZHQSDBMSHTN-ZIOFAICLSA-N
General description
Dynasore is a small molecule GTPase inhibitor that targets dynamin-1, dynamin-2 and Drp1 (mitochondrial). Dynasore blocks dynamin-dependent endocytosis, scission of endocytic vesicles. Dynosore is profibrotic, induces PAI-1 in pleural mesothelial cells, and may be an effective pleurodesing (pleurodesis) agent. Dynasor blocks human papillomavirus type 16 (HPV16) and bovine papillomavirus type 1 (BPV1) (pseudovirions) infections.
Dynasore hydrate lowers labile cholesterol in the plasma membrane and distorts lipid raft organization. Dynasore exhibits pleotropic effects on herpes simplex virus (HSV)-1 and HSV-2 infection. It hinders viral entry, trafficking of viral proteins and capsid formation.
Dynasore hydrate lowers labile cholesterol in the plasma membrane and distorts lipid raft organization. Dynasore exhibits pleotropic effects on herpes simplex virus (HSV)-1 and HSV-2 infection. It hinders viral entry, trafficking of viral proteins and capsid formation.
Application
Dynasore hydrate has been used:
- for priming fetal mesenchymal stem/stromal cells (fMSC)
- in confocal microscopy
- in wound healing/scratch and tube-formation assay
- to analyse its effects on Coxsackievirus A9 (CAV9) infection
- to inhibit clathrin-mediated endocytosis and caveolin-mediated endocytosis
- in live imaging of cells
Biochem/physiol Actions
Dynasore is a cell-permeable, reversible noncompetitive dynamin 1 and dynamin 2 GTPase activity inhibitor.
Features and Benefits
This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
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Ta pozycja | |||
|---|---|---|---|
| form powder | form powder | form solid | form solid |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. −20°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| solubility DMSO: ≥10 mg/mL, H2O: insoluble | solubility DMSO: >10 mg/mL | solubility DMSO: 16 mg/mL | solubility DMSO: 100 mg/mL |
| storage condition protect from light | storage condition protect from light | storage condition OK to freeze, protect from light | storage condition OK to freeze, protect from light |
| color off-white | color faintly yellow to dark yellow | color pale yellow | color yellow |
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Produkty
Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
Intracellular trafficking and endocytosis of CXCR4 in fetal mesenchymal stem/stromal cells
Pelekanos RA, et al.
BMC Cell Biology, 15(1), 15-15 (2014)
Richard H Tuligenga et al.
The lancet. Diabetes & endocrinology, 2(3), 228-235 (2014-03-14)
Type 2 diabetes increases the risk for dementia, but whether it affects cognition before old age is unclear. We investigated whether duration of diabetes in late midlife and poor glycaemic control were associated with accelerated cognitive decline. 5653 participants from
Tom Kirchhausen et al.
Methods in enzymology, 438, 77-93 (2008-04-17)
The large GTPase dynamin is essential for clathrin-dependent coated-vesicle formation. Dynasore is a cell-permeable small molecule that inhibits the GTPase activity of dynamin1, dynamin2 and Drp1, the mitochondrial dynamin. Dynasore was discovered in a screen of approximately 16,000 compounds for
Numer pozycji handlu globalnego
| SKU | NUMER GTIN |
|---|---|
| D7693-25MG | 04061832981444 |
| D7693-5MG | 04061833588765 |
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How can I store a solution of Product D7693, Dynasore hydrate?
1 answer-
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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What can I use to make a solution of Product D7693, Dynasore hydrate?
1 answer-
As listed on the product page on the website, Dynasore is soluble in DMSO at 10 mg/mL. It is also soluble in ethanol at 1 mg/mL.
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What concentration of Product D7693, Dynasore hydrate, should I use in my experiment?
1 answer-
The following reference uses Dynasore at 80 μM: Massol, R.H., et al., A burst of auxilin recruitment determines the onset of clathrin-coated vesicle uncoating. Proc. Nat. Acad. Sci., USA, 103, 10265-10270 (2006).
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