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Merck

D7011

Deoxyribonucleic acid sodium salt from human placenta

Type XIII

Synonim(y):

hpDNA, DNA

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Informacje o tej pozycji

Numer CAS:
9007-49-2
NACRES:
NA.51
UNSPSC Code:
41106305
MDL number:
MFCD00130922
Form:
powder
Storage temp.:
2-8°C

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type

Type XIII

form

powder

storage temp.

2-8°C

InChI

1S/C15H31N3O13P2/c16-13-1-7(20)11(28-13)5-25-32(21,22)31-9-3-15(18)29-12(9)6-26-33(23,24)30-8-2-14(17)27-10(8)4-19/h7-15,19-20H,1-6,16-18H2,(H,21,22)(H,23,24)

InChI key

AWBASQCACWFTGD-UHFFFAOYSA-N

General description

Deoxyribonucleic acid (DNA) from placenta and its methylation pattern is indicative of anomalies in the fetal growth. Tobacco smoking during pregnancy favors methylation and epigenetic modulation of placental DNA.

Application

Deoxyribonucleic acid sodium salt from human placenta has been used:
  • as a standard for optimization of digestion followed by high-performance liquid chromatography (HPLC) and mass spectroscopy[1]
  • as a standard for ultra violet (UV) spectrophotometer measurements
  • in polymerase chain reaction (PCR) assay and for standard curve generation for human papillomavirus type 6 quantification

Human placenta DNA (hpDNA) is a natural DNA used in studies of DNA binding anticancer agents and DNA binding agents that modulate DNA structure and function. Human placenta DNA is also used in physicochemical studies of DNA behavior in solution.
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Klasa składowania

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certyfikaty analizy (CoA)

Lot/Batch Number
SLBF0459V
SLBF5124V
109K3775
079K3791
127K37791

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Masz już ten produkt?

Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

DNA methylation in the human placenta and fetal growth
Koukoura O, et al.
Molecular Medicine Reports, 5(4), 883-889 (2012)
Johan S Nilsson et al.
Scientific reports, 9(1), 15432-15432 (2019-10-30)
Nasopharyngeal cancer (NPC) is associated with the Epstein-Barr virus (EBV). The clinical presentation and prognosis of NPC is well described, but not in relation to intralesional EBV-DNA load. In a retrospective design, 48 patients with NPC were examined. Patient history
Genome-wide DNA methylation study in human placenta identifies novel loci associated with maternal smoking during pregnancy
Morales E, et al.
International Journal of Epidemiology, 45(5), 1644-1655 (2016)
Viral load and m RNA expression of HPV type 6 among cases with recurrent respiratory papillomatosis
Forslund O, et al.
Laryngoscope, 126(1), 122-127 (2016)
Results from the NIST 2004 DNA quantitation study
Kline MC, et al.
Journal of Forensic Sciences, 50(3), 1-8 (2005)
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Numer pozycji handlu globalnego

SKUNUMER GTIN
D7011-25MG04061833289471
D7011-1MG04061833588123
D7011-250MG04061833289464
D7011-5MG04061833289488

Questions

  1. This item (D7011) has been discontinued. Can you please let me know what the comparable product is?

    1 answer

    1. Product D3035, is a solution of Deoxyribonucleic acid prepared from human placenta at a concentration of 0.05 mg/mL (the 0.1 mg pack size would be 2 mL) and would be the closest equivalent alternative to the discontinued D7011. Please see the link below to review this product:
      https://www.sigmaaldrich.com/product/sigma/d3035

      If a powdered form is preferred we do offer comparable alternatives such as 11691112001 from Roche, Human Genomic DNA from human blood (buffy coat). It is not from human placenta but prepared from 100 to 200 individual blood donors of both sexes (pool of the buffy coat). If the DNA from another species is compatible in your application, products D1626 (from salmon) or D6898 (from herring) are options to consider.

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