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D3072

Sigma-Aldrich

Doxycycline Hydrochloride, Ready Made Solution

100 mg/mL in DMSO, ≥95.0% (HPLC)

Synonim(y):

Chlorowodorek α-6-dezoksy-5-hydroksytetracykliny

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1 ML
332,00 zł

332,00 zł

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1 ML
332,00 zł

About This Item

Wzór empiryczny (zapis Hilla):
C22H24N2O8 · HCl
Numer CAS:
10592-13-9
Masa cząsteczkowa:
480.90
Numer MDL:
MFCD03427564
Kod UNSPSC:
51284028
NACRES:
NA.85

332,00 zł

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pochodzenie biologiczne

synthetic

Poziom jakości

200

sterylność

0.22 μm filtered

Próba

≥95.0% (HPLC)

Formularz

liquid

stężenie

100 mg/mL in DMSO

rozpuszczalność

DMSO: 100 mg/mL

spektrum działania antybiotyku

Gram-negative bacteria
Gram-positive bacteria
mycoplasma
parasites

Tryb działania

protein synthesis | interferes

temp. przechowywania

−20°C

InChI

1S/C22H24N2O8.ClH/c1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29;/h4-7,10,14-15,17,25-27,31-32H,23H2,1-3H3;1H/b21-13-;/t7-,10+,14+,15-,17-,22-;/m0./s1

Klucz InChI

VLUQVUWDECWBTL-UQVCFKGQSA-N

Powiązane kategorie

Opis ogólny

Doxycycline is a member of the tetracycline antibiotics group, and is commonly used to treat a variety of infections. It is a Broad spectrum antibiotic and bacteriostatic. Doxycycline shows antiprotozoal properties and is a potent inhibitor of MMPs (matrix metalloproteinases) in vivo.

Zastosowanie

<ul>
<li><strong>AAPS PharmSciTech: </strong>Stworzenie nanowłóknistej membrany na bazie PVA/PCL/CS zawierającej chlorowodorek doksycykliny do sterowanej regeneracji tkanek i kontrolowanego dostarczania w leczeniu zapalenia przyzębia, oceniane in vivo u szczurów (Mirzaeei et al, 2024).</li>
<li><strong>European Journal of Pharmacology: </strong>Rola chlorowodorku doksycykliny w hamowaniu progresji złośliwego guza rabdoidalnego nerki poprzez celowanie w MMP17 i MMP1 poprzez szlak sygnałowy PI3K-Akt (Mi et al., 2024).</li>
</ul>

Inne uwagi

Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.
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Kod klasy składowania

10 - Combustible liquids

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

188.6 °F - closed cup

Temperatura zapłonu (°C)

87 °C - closed cup

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Certyfikaty analizy (CoA)

Lot/Batch Number
0000419621
0000419621
0000408895
0000408895
0000366924

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Odwiedź Bibliotekę dokumentów

Megan E Forrest et al.
PloS one, 15(2), e0228730-e0228730 (2020-02-14)
Messenger RNA (mRNA) degradation plays a critical role in regulating transcript levels in the cell and is a major control point for modulating gene expression. In yeast and other model organisms, codon identity is a powerful determinant of transcript stability
Youcai Tang et al.
PloS one, 13(8), e0200897-e0200897 (2018-08-02)
Alpha-1 Antitrypsin (α1AT) Deficiency is a genetic disease in which accumulation of α1AT mutant Z (α1ATZ) protein in the ER of hepatocytes causes chronic liver injury, liver fibrosis, and hepatocellular carcinoma. No effective medical therapy is currently available for the
Adam W Whisnant et al.
Nature communications, 11(1), 2038-2038 (2020-04-29)
The predicted 80 open reading frames (ORFs) of herpes simplex virus 1 (HSV-1) have been intensively studied for decades. Here, we unravel the complete viral transcriptome and translatome during lytic infection with base-pair resolution by computational integration of multi-omics data.
Benedetta Assetta et al.
Journal of visualized experiments : JoVE, (165) (2020-11-24)
In Alzheimer's disease (AD) and other neurodegenerative disorders, oligodendroglial failure is a common early pathological feature, but how it contributes to disease development and progression, particularly in the gray matter of the brain, remains largely unknown. The dysfunction of oligodendrocyte
Sungryong Oh et al.
Nucleic acids research, 48(16), 9037-9052 (2020-08-01)
Epigenetic regulation is important for establishing lineage-specific gene expression during early development. Although signaling pathways have been well-studied for regulation of trophectoderm reprogramming, epigenetic regulation of trophectodermal genes with histone modification dynamics have been poorly understood. Here, we identify that
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Questions

1–4 of 4 Questions  

  1. How many times can I thaw and freeze this product?

    1 answer

    1. There is no recommended or maximum number of freeze/thaw cycles for this product. It is advisable to store in aliquots to minimize freeze/thaw cycles.

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  3. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  4. What is the concentration of this 1 ml Doxycycline solution?

    1 answer

    1. This product is a ready made solution with a concentration of 100 mg/mL in DMSO. The concentration is listed in the "Properties" section of the product page.

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