C9658
Carboxypeptidase G from Pseudomonas sp.
lyophilized powder, ≥3 units/mg protein
Synonim(y):
γ-Glutamyl hydrolase
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5 UNITS
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Informacje o tej pozycji
Numer CAS:
UNSPSC Code:
12352204
NACRES:
NA.54
EC Number:
232-978-1
MDL number:
Specific activity:
≥3 units/mg protein
Przejdź do
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Pozwól nam pomócform
lyophilized powder
Quality Level
specific activity
≥3 units/mg protein
mol wt
homodimer ~90 kDa
composition
Protein, ~70% biuret
solubility
H2O: soluble 0.5 mg/mL
storage temp.
−20°C
Powiązane kategorie
1 of 4
Ta pozycja | |||
|---|---|---|---|
| specific activity ≥3 units/mg protein | specific activity ≥125 units/mg protein | specific activity ≥50 units/mg protein | specific activity ≥50 units/mg protein |
| form lyophilized powder | form lyophilized powder | form ready-to-use solution | form lyophilized powder |
| mol wt homodimer ~90 kDa | mol wt 34,000 Da± 600 | mol wt ~35 kDa | mol wt 61 kDa |
| storage temp. −20°C | storage temp. −20°C | storage temp. 2-8°C | storage temp. −20°C |
| solubility H2O: soluble 0.5 mg/mL | solubility - | solubility - | solubility - |
| Quality Level 300 | Quality Level 200 | Quality Level 300 | Quality Level 200 |
Application
Carboxypeptidase G from Pseudomonas sp., or γ-Glutamyl hydrolase, has been used in a study to assess the role of the putidaredoxin COOH-terminus in P-450cam (cytochrome m) hydroxylations. Carboxypeptidase G from Pseudomonas sp. has also been used in a study to investigate the effects of nitric oxide on pemetrexed cytotoxicity via NO‑cGMP signaling in lung adenocarcinoma cells.
Biochem/physiol Actions
Carboxypeptidase G is a lysosomal, thiol-dependent protease, which progressively cleaves γ-glutamyl pteroyl poly-γ-glutamate yielding pteroyl-α-glutamate (folic acid) and free glutamate. It is considered highly specific for the γ-glutamyl bond, but not for the C-terminal amino acid of the leaving group.[1] Molecular mass of this homodimer is approximately 90 kDa. The enzyme is activated by Zn2+ ions.
Physical form
Contains sodium acetate salt.
Preparation Note
Chromatographically purified
Solutions should be prepared fresh prior to use.
Other Notes
One unit will hydrolyze 1.0 μmole of L-glutamic acid from (+)amethopterin per min at pH 7.3 at 30 °C.
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signalword
Danger
hcodes
Hazard Classifications
Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Klasa składowania
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Edgar M Pera et al.
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Endoderm development is an area of intense interest in developmental biology, but progress has been hampered by the lack of specific markers for differentiated endodermal cells. In an unbiased secretion cloning screen of Xenopus gastrula embryos we isolated a novel
The enzymatic hydrolysis of methotrexate and folic acid.
C C Levy et al.
The Journal of biological chemistry, 242(12), 2933-2938 (1967-06-25)
Klára Hlouchová et al.
Journal of neurochemistry, 101(3), 682-696 (2007-01-24)
Human glutamate carboxypeptidase II (GCPII) is a transmembrane metallopeptidase found mainly in the brain, small intestine, and prostate. In the brain, it cleaves N-acetyl-L-aspartyl-glutamate, liberating free glutamate. Inhibition of GCPII has been shown to be neuroprotective in models of stroke
Luz I A Calderon-Villalobos et al.
The Plant cell, 17(9), 2473-2485 (2005-07-19)
In this study, we characterize the evolutionarily conserved TOUGH (TGH) protein as a novel regulator required for Arabidopsis thaliana development. We initially identified TGH as a yeast two-hybrid system interactor of the transcription initiation factor TATA-box binding protein 2. TGH
S G Sligar et al.
Proceedings of the National Academy of Sciences of the United States of America, 71(10), 3906-3910 (1974-10-01)
Methylene hydroxylation by cytochrome P-450(cam) (cytochrome m) can be resolved into four distinct steps: substrate addition, m(o) --> m(os); reduction, m(os) --> m(rs); dioxygen addition, m(rs) --> m(O2) (rs); followed by a second putidaredoxin (Pseudomonas putida ferredoxin)-mediated reduction and product
Powiązane treści
Numer pozycji handlu globalnego
| SKU | NUMER GTIN |
|---|---|
| C9658-5UN | 04061832700441 |
| C9658-20UN | 04061832700434 |
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