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C9658
Carboxypeptidase G from Pseudomonas sp.
lyophilized powder, ≥3 units/mg protein
Synonim(y):
γ-Glutamyl hydrolase
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| Gabaryty przesyłki | SKU | Dostępność | Cena netto |
|---|---|---|---|
| 5 units | Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności | 2080,00 zł | |
| 20 units | Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności | 3690,00 zł 3136,50 zł |
Informacje o tej pozycji
Numer CAS:
UNSPSC Code:
12352204
NACRES:
NA.54
EC Number:
232-978-1
MDL number:
Specific activity:
≥3 units/mg protein
2080,00 zł
Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności
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Pozwól nam pomócform
lyophilized powder
Quality Level
specific activity
≥3 units/mg protein
mol wt
homodimer ~90 kDa
composition
Protein, ~70% biuret
solubility
H2O: soluble 0.5 mg/mL
storage temp.
−20°C
Application
Carboxypeptidase G from Pseudomonas sp., or γ-Glutamyl hydrolase, has been used in a study to assess the role of the putidaredoxin COOH-terminus in P-450cam (cytochrome m) hydroxylations. Carboxypeptidase G from Pseudomonas sp. has also been used in a study to investigate the effects of nitric oxide on pemetrexed cytotoxicity via NO‑cGMP signaling in lung adenocarcinoma cells.
Biochem/physiol Actions
Carboxypeptidase G is a lysosomal, thiol-dependent protease, which progressively cleaves γ-glutamyl pteroyl poly-γ-glutamate yielding pteroyl-α-glutamate (folic acid) and free glutamate. It is considered highly specific for the γ-glutamyl bond, but not for the C-terminal amino acid of the leaving group.[1] Molecular mass of this homodimer is approximately 90 kDa. The enzyme is activated by Zn2+ ions.
Physical form
Contains sodium acetate salt.
Preparation Note
Chromatographically purified
Solutions should be prepared fresh prior to use.
Other Notes
One unit will hydrolyze 1.0 μmole of L-glutamic acid from (+)amethopterin per min at pH 7.3 at 30 °C.
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Ta pozycja | |||
|---|---|---|---|
| specific activity ≥3 units/mg protein | specific activity ≥125 units/mg protein | specific activity ≥50 units/mg protein | specific activity ≥50 units/mg protein |
| form lyophilized powder | form lyophilized powder | form ready-to-use solution | form lyophilized powder |
| storage temp. −20°C | storage temp. −20°C | storage temp. 2-8°C | storage temp. −20°C |
| mol wt homodimer ~90 kDa | mol wt 34,000 Da± 600 | mol wt ~35 kDa | mol wt 61 kDa |
| solubility H2O: soluble 0.5 mg/mL | solubility - | solubility - | solubility - |
| Quality Level 300 | Quality Level 200 | Quality Level 300 | Quality Level 200 |
signalword
Danger
hcodes
Hazard Classifications
Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Klasa składowania
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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The role of Glutamate (Glu), one of the major excitatory neurotransmitters in the central nervous system, has been thoroughly investigated in animal models and in humans in several physiologic events, such as brain development and synaptic plasticity, but also in
Numer pozycji handlu globalnego
| SKU | NUMER GTIN |
|---|---|
| C9658-20UN | 04061832700434 |
| C9658-5UN | 04061832700441 |