C5235

Cytochrome P450 human

Name: Cytochrome P450 human
Brand: SIGMA

4F3B isozyme microsomes, with P450 Reductase and cytochrome b₅, recombinant, expressed in baculovirus infected insect cells (BTI-TN-5B1-4)

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Informacje o tej pozycji

UNSPSC Code:

12161501

NACRES:

NA.47

Numer WE:

1.6.2.4 (BRENDA, IUBMB)

MDL number:

MFCD03456520

Biological source:

human

Recombinant:

expressed in baculovirus infected insect cells (BTI-TN-5B1-4)

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biological source

human

recombinant

expressed in baculovirus infected insect cells (BTI-TN-5B1-4)

form

solution

mol wt

45-60 kDa

packaging

vial of 0.5 nmol

UniProt accession no.

Q08477

application(s)

cell analysis

shipped in

dry ice

storage temp.

−70°C

Quality Level

200

Gene Information

human ... CYP4F3(4051)

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Ta pozycja	C4982	C3735	C3860
Sigma-Aldrich C5235 Cytochrome P450 human	Sigma-Aldrich C4982 Cytochrome P450 human	Sigma-Aldrich C3735 Cytochrome P450 human	Sigma-Aldrich C3860 Cytochrome P450 human
Gene Information human ... CYP4F3(4051)	Gene Information human ... CYP3A4(1576)	Gene Information human ... CYP1A1(1543)	Gene Information human ... CYP1B1(1545)
biological source human	biological source human	biological source human	biological source human
recombinant expressed in baculovirus infected insect cells (BTI-TN-5B1-4)	recombinant expressed in baculovirus infected insect cells (BTI-TN-5B1-4)	recombinant expressed in baculovirus infected insect cells (BTI-TN-5B1-4)	recombinant expressed in baculovirus infected insect cells (BTI-TN-5B1-4)
form solution	form solution	form solution	form solution
application(s) cell analysis	application(s) cell analysis	application(s) cell analysis	application(s) cell analysis
UniProt accession no. Q08477	UniProt accession no. P08684	UniProt accession no. P04798	UniProt accession no. Q16678

Biochem/physiol Actions

Cytochrome P450 is a heterogeneous family of isozymes whose primary function is to oxidize small molecules, both as a function of intermediary metabolism (e.g., fatty acids) and to detoxify exogenous compounds (drugs or toxins). Some isoforms have narrow substrate specificity, while others are promiscuous. The CYP1A1 isoform catalyzes 7-deethylation of ethoxyresorufin. Cytochrome P450 (CYP) plays an important role in detoxifying xenobiotics, cellular metabolism and homeostasis. One of the main mechanisms of drug-drug interactions is the induction or inhibition of these enzymes. CYP enzymes are transcriptionally activated by a variety of xenobiotics and by endogenous substrates via receptor-dependent pathways. Inhibition of these enzymes is a major factor in metabolism-based drug-drug interactions, and many chemotherapeutic medications can cause drug interactions by either inhibiting or inducing the cytochrome p450 enzyme system.

The CYP4F3B isoform catalyzes the 20-hydroxylation of leukotriene B₄.

Physical form

Solution in 100 mM potassium phosphate buffer, pH 7.4.

Other Notes

One unit will reduce 1 nanomole of cytochrome C per minute at pH 7.4 at 37 deg C.

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Klasa składowania

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Expression of the CYP4F3 gene. tissue-specific splicing and alternative promoters generate high and low K(m) forms of leukotriene B(4) omega-hydroxylase.

P Christmas et al.

The Journal of biological chemistry, 274(30), 21191-21199 (1999-07-20)

Cytochrome P450 4F3 (CYP4F3) catalyzes the inactivation of leukotriene B(4) by omega-oxidation in human neutrophils. To understand the regulation of CYP4F3 expression, we analyzed the CYP4F3 gene and cloned a novel isoform (CYP4F3B) that is expressed in fetal and adult

Time- and NADPH-dependent inhibition of cytochrome P450 3A4 by the cyclopentapeptide cilengitide: significance of the guanidine group and accompanying spectral changes.

Mirza Bojić et al.

Drug metabolism and disposition: the biological fate of chemicals, 42(9), 1438-1446 (2014-07-06)

Cilengitide is a stable cyclic pentapeptide containing an Arg-Gly-Asp motif responsible for selective binding to αVβ3 and αVβ5 integrins. The candidate drug showed unexpected inhibition of cytochrome P450 (P450) 3A4 at high concentrations, that is, a 15-mM concentration caused attenuation

Cytochrome p450-mediated metabolic activation of diosbulbin B.

Dongju Lin et al.

Drug metabolism and disposition: the biological fate of chemicals, 42(10), 1727-1736 (2014-07-16)

Diosbulbin B (DIOB), a furan-containing diterpenoid lactone, is the most abundant component of Dioscorea bulbifera L. (DB), a traditional Chinese medicine herb. Administration of purified DIOB or DB extracts has been reported to cause liver injury in animals. The mechanisms

In vitro metabolism of 20(R)-25-methoxyl-dammarane-3, 12, 20-triol from Panax notoginseng in human, monkey, dog, rat, and mouse liver microsomes.

Xiangrong Zhang et al.

PloS one, 9(4), e94962-e94962 (2014-04-17)

The present study characterized in vitro metabolites of 20(R)-25-methoxyl-dammarane-3β, 12β, 20-triol (20(R)-25-OCH3-PPD) in mouse, rat, dog, monkey and human liver microsomes. 20(R)-25-OCH3-PPD was incubated with liver microsomes in the presence of NADPH. The reaction mixtures and the metabolites were identified

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Cytochrome P450 human