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C4801

Cyclo(7-aminoheptanoyl-Phe-D-Trp-Lys-Thr[Bzl])

Name: Cyclo(7-aminoheptanoyl-Phe-<SC>D</SC>-Trp-Lys-Thr[Bzl])
Brand: SIGMA

≥95% (HPLC), powder

Synonim(y):

Cyclosomatostatin

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Informacje o tej pozycji

Wzór empiryczny (zapis Hilla):

C₄₄H₅₇N₇O₆

Numer CAS:

84211-54-1

Masa cząsteczkowa:

779.97

NACRES:

NA.32

PubChem Substance ID:

24892727

UNSPSC Code:

12352200

MDL number:

MFCD00076778

Assay:

≥95% (HPLC)

Form:

powder

Quality level:

200

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Właściwości

Quality Level

200

assay

≥95% (HPLC)

form

powder

color

white

solubility

H₂O: 1 mg/mL, clear, colorless

storage temp.

−20°C

SMILES string

O=C(N[C@H](C(N[C@@]1([H])[C@@H](C)OCC2=CC=CC=C2)=O)CCCCN)[C@H](NC([C@@H](NC(CCCCCCNC1=O)=O)CC3=CC=CC=C3)=O)CC4=CNC5=C4C=CC=C5

InChI

1S/C44H57N7O6/c1-30(57-29-32-18-8-5-9-19-32)40-44(56)46-25-15-3-2-10-23-39(52)48-37(26-31-16-6-4-7-17-31)42(54)50-38(27-33-28-47-35-21-12-11-20-34(33)35)43(55)49-36(41(53)51-40)22-13-14-24-45/h4-9,11-12,16-21,28,30,36-38,40,47H,2-3,10,13-15,22-27,29,45H2,1H3,(H,46,56)(H,48,52)(H,49,55)(H,50,54)(H,51,53)/t30-,36+,37+,38-,40+/m1/s1

InChI key

YHVHQZYJGWGAKN-ZUWUZHNASA-N

Gene Information

human ... SST(6750)
mouse ... SST(20604)
rat ... SST(24797)

Opis

Application

Cyclo(7-aminoheptanoyl-Phe-D-Trp-Lys-Thr[Bzl]) has been used as a somatostatin antagonist to study its effects on sleep in rats to infer the role of endogenous somatostatin in the physiologic modulation of REM sleep (REMS) [1], as an somatostatin (SST) antagonist to study its effects on elemental-induced intestinal atrophy in rats , as an SST receptor antagonist to eliminate the effect of somatostatin on catecholamine .

Biochem/physiol Actions

Cyclo(7-aminoheptanoyl-Phe-D-Trp-Lys-Thr[Bzl]) (cSSTA) is a cyclic somatostatin (SST) analog and is a somatostatin receptor antagonist. It is involved in blocking the effect of somatostatin, such as airway β-adrenergic function and regulation of acetylcholine release. cSSTA is also involved in blocking the effect of somatostatin of hormone release and corticotropin-releasing factor-induced suppression of gastric emptying.[2]

Cyclo(7-aminoheptanoyl-Phe-D-Trp-Lys-Thr[Bzl]), also known as cyclosomatostatin. Inhibition of somatostatin receptors by cyclosomatostatin induces catalepsy in rats.

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Ta pozycja	D9378	C2901	Q4990
Sigma-Aldrich C4801 Cyclo(7-aminoheptanoyl-Phe-D-Trp-Lys-Thr[Bzl])	Sigma-Aldrich D9378 3,4-Dihydroxy-D-phenylalanine	Sigma-Aldrich C2901 Cholecystokinin (CCK) Fragment 26-33 Amide, Non-sulfated	Sigma-Aldrich Q4990 QBP1
form powder	form powder	form powder	form powder
assay ≥95% (HPLC)	assay ≥95%	assay ≥95% (HPLC)	assay ≥95% (HPLC)
Quality Level 200	Quality Level 100	Quality Level 200	Quality Level 100
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. −20°C
solubility H₂O: 1 mg/mL, clear, colorless	solubility 1 M HCl: soluble, ethanol: insoluble	solubility -	solubility H₂O: >1 mg/mL
color white	color -	color -	color white

Klasa składowania

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certyfikaty analizy (CoA)

Lot/Batch Number

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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Evidence that endogenous somatostatin (SRIF) exerts an inhibitory control on the function and growth of rat adrenal zona glomerulosa. The possible involvement of zona medullaris as a source of endogenous SRIF.

P Rebuffat et al.

The Journal of steroid biochemistry and molecular biology, 48(4), 353-360 (1994-03-01)

The effect of SRIF and its antagonist cyclo(7-aminoheptanonyl-Phe-D-Trp-Lys-Thr magnitude of Bzl)(SRIF-A) were studied in sham-operated and bilaterally adrenalectomized rats bearing ACTH- and angiotensin II (ANG-II)-responsive adrenocortical autotransplants. SRIF-A (10(-5) M) completely annulled SRIF (10(-6) M)-induced inhibition of ANG-II (10(-8) M)-evoked

Cholecystokinin type A receptors mediate intestinal fat-induced inhibition of acid secretion through somatostatin-14 in dogs.

L Fung et al.

Endocrinology, 134(6), 2376-2382 (1994-06-01)

This study was designed to examine whether one or both principle molecular forms of somatostatin (SLI), somatostatin-28 (S-28) and somatostatin-14 (S-14), mediate inhibition of stimulated gastric acid by intestinal fat and to determine whether the mode of action includes activation

In vitro effects of methionine-enkephalin, somatostatin and insulin on cultured gonadal cells of the snail Helix aspersa.

Z Monnier et al.

Experientia, 51(8), 824-830 (1995-08-16)

Isolated snail gonadal cells were cultured in the presence of synthetic neuropeptides in order to determine the subsequent effect of these substances on gonadal synthetic activities. Gonadal cells were incubated for 24 h in concentrations of methionine-enkephalin, somatostatin and insulin

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Numer pozycji handlu globalnego

SKU	NUMER GTIN
C4801-1MG	04061826152577

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