C2932

Chelerythrine chloride

plant, ≥95% (TLC), protein kinase C inhibitor, powder

• Synonim(y): 1,2-Dimethoxy-N-methyl(1,3)benzodioxolo(5,6-c)phenanthridinium chloride, Toddaline chloride
• Wzór empiryczny (zapis Hilla): C₂₁H₁₈ClNO₄
• Numer CAS: 3895-92-9
• Masa cząsteczkowa: 383.82
• UNSPSC Code: 12352200
• PubChem Substance ID: 24278305
• NACRES: NA.77
• MDL number: MFCD00060717
• Assay: ≥95% (TLC)
• Form: powder

Właściwości

• Nazwa produktu: Chelerythrine chloride, ≥95% (TLC), powder
• biological source: plant
• Quality Segment: 100
• assay: ≥95% (TLC)
• form: powder
• color: yellow to orange
• mp: 213.0-214.0 °C
• solubility: DMSO: 2 mg/mL
• storage temp.: −20°C
• SMILES string: Cl.COc1ccc2-c3ccc4cc5OCOc5cc4c3[N](C)=Cc2c1OC
• InChI: 1S/C21H18NO4.ClH/c1-22-10-16-13(6-7-17(23-2)21(16)24-3)14-5-4-12-8-18-19(26-11-25-18)9-15(12)20(14)22;/h4-10H,11H2,1-3H3;1H
• InChI key: SUPBMPBJXZDANZ-UHFFFAOYSA-N

Opis

General description

Chelerythrine chloride (CHE), a benzophenanthridine alkaloid is an inhibitor of protein kinase C (PKC). It is the active component of Macleaya cordata.

Application

Chelerythrine chloride has been used:

• as a supplement in heat-inactivated late-embryo extract or late-embryo extract to inhibit protein kinase C (PKC) activity
• for in vitro Xenopus experiments
• as a PKC inhibitor in HL-1 cells, to block the PKC pathway to study its effects on doxazosin-induced galectin-3 and collagen expression

Biochem/physiol Actions

Chelerythrine chloride (CHE) is capable of preventing the growth and apoptosis in human gastric cancer BGC-823 cells. It possesses several biological effects and also can induce the phosphorylation of a ~20 kDa protein present in the mitochondrial fraction of the rat retina.

Features and Benefits

This compound is featured on the P2 Receptors: P2X Ion Channel Family and PKC pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Ta strona może zawierać tekst przetłumaczony maszynowo.

Informacja o środkach bezpieczeństwa

• pictograms: GHS07
• signalword: Warning
• hcodes: H302 + H312 + H332,H315,H319,H335
• pcodes: P261 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable