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C1163
Complement C5 deficient serum human
for complement assays
Synonim(y):
Complement serum
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| Gabaryty przesyłki | SKU | Dostępność | Cena netto |
|---|---|---|---|
| 1 mL | Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności | 1170,00 zł |
Informacje o tej pozycji
NACRES:
NA.61
UNSPSC Code:
12352202
Form:
solution
Biological source:
human
1170,00 zł
Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności
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Ta pozycja | |||
|---|---|---|---|
| technique(s) activity assay: suitable | technique(s) activity assay: suitable | technique(s) activity assay: suitable | technique(s) activity assay: suitable |
| biological source human | biological source human serum | biological source human | biological source human |
| form solution | form solution | form liquid | form solution |
| UniProt accession no. | UniProt accession no. | UniProt accession no. | UniProt accession no. |
| storage temp. −70°C | storage temp. −70°C | storage temp. −70°C | storage temp. −70°C |
| Gene Information human ... C5(727) | Gene Information human ... C5(727) | Gene Information human ... C2(717) | Gene Information human ... C3(718) |
Application
Complement C5 deficiencies in humans are rare, but often associated with recurrent infections by Neisseria spp. (such as meningitis). Deficiency in C5 results in an impairment of hemolytic activity from both the classical and alternative pathway of the complement system. Recently, genetic research has revealed that a 153 bp deletion in exon 30 results in complete C5 deficiency. Research has also implicated C5 deficiency in a predisposition to cardiac dysfunction when cardiac injury occurs.
Biochem/physiol Actions
Complement C5 deficiency can, paradoxically, protect against certain effects of infection. Patients deficient in C5 are unusually susceptible to meningococcal infection, but have a milder course of infection. Reduced expression of tumor necrosis factor (TNF) may account for this effect.[1]
Physical form
Supplied as a solution in PBS, pH 7.4
Analysis Note
C5 is depleted by immunoadsorption as determined by hemolytic assay.
Disclaimer
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
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Klasa składowania
12 - Non Combustible Liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
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The key roles of macrophages in atherosclerosis include the phagocytosis of apoptotic and necrotic cells and cell debris, whose accumulation in atherosclerotic lesions exacerbates inflammation and promotes plaque vulnerability. Evidence is accumulating that macrophage phagocytic functions peak at the early
P A Barton et al.
Infection and immunity, 61(4), 1474-1481 (1993-04-01)
Patients with disseminated Neisseria meningitidis infections (meningococcemia) suffer from a fulminant shock syndrome that is accompanied by extraordinarily high concentrations in serum of tumor necrosis factor (TNF). People with homozygous deficiencies of late complement components (C5, C6, C7, and C8)
A novel role for the fifth component of complement (C5) in cardiac physiology.
Mullick A., et al.
PLoS ONE, 6 (2011)
P Aguilar-Ramirez et al.
Molecular immunology, 46(10), 2116-2123 (2009-04-21)
The deficiency of complement C5 is rare and frequently associated with severe and recurrent infections, especially caused by Neisseria spp. We observed the absence of component C5 in the serum of 3 siblings from a Brazilian family with history of
Numer pozycji handlu globalnego
| SKU | NUMER GTIN |
|---|---|
| C1163-1ML | 04061833461549 |
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