B5057

7-Benzyloxy-4-trifluoromethylcoumarin

Name: 7-Benzyloxy-4-trifluoromethylcoumarin
Brand: SIGMA
Price: 2940 PLN

≥99% (HPLC), solid

Synonim(y):

7-BFC

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5 MG

2940,00 zł

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Informacje o tej pozycji

Wzór empiryczny (zapis Hilla):

C₁₇H₁₁F₃O₃

Masa cząsteczkowa:

320.26

UNSPSC Code:

12161501

PubChem Substance ID:

24891807

NACRES:

NA.47

MDL number:

MFCD01564466

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Nazwa produktu

7-Benzyloxy-4-trifluoromethylcoumarin, ≥99% (HPLC), solid

Quality Level

100

assay

≥99% (HPLC)

form

solid

storage temp.

−20°C

SMILES string

FC(F)(F)C1=CC(=O)Oc2cc(OCc3ccccc3)ccc12

InChI

1S/C17H11F3O3/c18-17(19,20)14-9-16(21)23-15-8-12(6-7-13(14)15)22-10-11-4-2-1-3-5-11/h1-9H,10H2

InChI key

WVKLERKKJXUPIK-UHFFFAOYSA-N

Gene Information

rat ... Maoa(29253), Maob(25750)

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Ta pozycja	C6608	A0466	164545
Sigma-Aldrich B5057 7-Benzyloxy-4-trifluoromethylcoumarin	Sigma-Aldrich C6608 N-Acetyl-Lys-Pro-Arg-7-amido-4-trifluoromethylcoumarin	Sigma-Aldrich A0466 N-Acetyl-Asp-Glu-Val-Asp-7-amido-4-trifluoromethylcoumarin	Sigma-Aldrich 164545 7-Amino-4-methylcoumarin
assay ≥99% (HPLC)	assay ≥95% (HPLC)	assay ≥90% (HPLC)	assay ≥98% (HPLC)
Quality Level 100	Quality Level 200	Quality Level 200	Quality Level 100
form solid	form solid	form powder	form solid
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. 2-8°C
Gene Information rat ... Maoa(29253), Maob(25750)	Gene Information -	Gene Information human ... CASP3(836)	Gene Information -

Application

7-Benzyloxy-4-trifluoromethylcoumarin has been used:

in the SBAD2-3x-AAGLY hepatocyte-like cell (HLC) functional assay to measure the cytochrome P450 3A4 (CYP3A4)-dependent activity
in O-dealkylation reaction to determine the activity of CYP3A
to measure the activity of CYP3A-mediated 7-benzyloxy-4-trifluoromethylcoumarin O-debenzylase activity (BFCOD)

Biochem/physiol Actions

Metabolized primarily by cytochrome P450 isozymes CYP1A2 and CYP3A4.

Legal Information

Supplied by Gentest Corp., U.S. Patent Nos. 6,207,404.

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pictograms

GHS07

signalword

Warning

hcodes

H302 + H312 + H332

pcodes

P261 - P264 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312

Hazard Classifications

Acute Tox. 4 Oral

Klasa składowania

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Interactive effects of selected pharmaceutical mixtures on bioaccumulation and biochemical status in crucian carp (Carassius auratus).

Jiannan Ding et al.

Chemosphere, 148, 21-31 (2016-01-23)

The aim of this study was to evaluate the interactive effects of fluoxetine (FLU), roxithromycin (ROX) and propranolol (PRP) on the bioaccumulation and biochemical responses in the crucian carp Carassius auratus. After 7 days of binary exposure (ROX + FLU

Accumulation, tissue distribution, and biochemical effects of polystyrene microplastics in the freshwater fish red tilapia (Oreochromis niloticus).

Jiannan Ding et al.

Environmental pollution (Barking, Essex : 1987), 238, 1-9 (2018-03-13)

While the presence of microplastics (MPs) in marine environments has been detected worldwide, the importance of MPs pollution in freshwater environments has also been emphasized in recent years. However, the body of knowledge regarding the biological effects of MPs on

A non-destructive BFCOD assay for in vivo measurement of cytochrome P450 3A (CYP3A) enzyme activity in fish embryos and larvae.

Elias M Oziolor et al.

Ecotoxicology (London, England), 26(6), 809-819 (2017-06-08)

There is increasing interest in quantifying the exposure and effects of anthropogenic contaminants in fish. Determination of exposures in wild fish is routinely performed, but methods to investigate potential effects are less established. One of the most relevant approaches would

Immortalization of human hepatocytes from biliary atresia with CDK4R24C, cyclin D1, and TERT for cytochrome P450 induction testing.

Manami Nishiwaki et al.

Scientific reports, 10(1), 17503-17503 (2020-10-17)

Hepatocytes are an important tool for in vitro toxicology testing. In addition to primary cultures, a limited number of immortalized cell lines have been developed. We here describe a new cell line, designated as HepaMN, which has been established from

PXR mediated induction of CYP3A4, CYP1A2, and P-gp by Mitragyna speciosa and its alkaloids.

Vamshi K Manda et al.

Phytotherapy research : PTR, 31(12), 1935-1945 (2017-10-27)

Kratom (Mitragyna speciosa), a native herb of Southeast Asia, is widely known for its psychoactive properties. Recent increase in the use of kratom as a recreational drug has increased the risk of its interaction with conventional drugs if taken concomitantly.

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Numer pozycji handlu globalnego

SKU	NUMER GTIN
B5057-5MG	04061833433577

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