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A6861
Acetyl-CoA carboxylase 2 human
recombinant, expressed in Sf9 cells
Synonim(y):
ACACB, ACC2, acetyl-CoA carboxylase beta
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| Gabaryty przesyłki | SKU | Dostępność | Cena netto |
|---|---|---|---|
| 10 μg | Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności | 3690,00 zł |
3690,00 zł
Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności
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Pozwól nam pomócGeneral description
C-terminal HIS-tagged 277 kDa full length protein
Application
Acetyl-CoA carboxylase is responsible for synthesis of Malonyl-CoA which is an inhibitor of fatty acid oxidation in skeletal muscle mitochondria. The enzyme may be used to study the effect on production of malonyl-CoA as well as fatty acid oxidation during exercise.[1] The enzyme also may be used for ACC regulation study in anti-obesity and anti-type 2 diabetes therapeutics.[2]
Biochem/physiol Actions
Acetyl-CoA Carboxylase (ACC) regulates the metabolism of fatty acids. This enzyme catalzes the formation of Malonyl CoA through the irreversible carboxylation of acetyl CoA. There are two main isoforms of Acetyl-CoA carboxylase expressed in mammals, Acetyl-CoA carboxylase 1 (ACACA) and Acetyl-CoA carboxylase 2 (ACACB). ACACA has broad tissue distribution but is enriched in tissues critical for fatty acid sythesis such as adipose tissue. ACACB is enriched in tissues such as skeletal muscle and heart that are critical for fatty acid oxidation.
The Acetyl-CoA Carboxylase enzymes are activated by citrate, glutamate, and dicarboxylic acids and negatively regulated by long and short chain fatty acyl CoAs. Because of thier roles in fatty acid metabolism and oxidation, ACACA and ACACB are therapeutic targets for treating obesity and metabolic syndrome disorders.
The Acetyl-CoA Carboxylase enzymes are activated by citrate, glutamate, and dicarboxylic acids and negatively regulated by long and short chain fatty acyl CoAs. Because of thier roles in fatty acid metabolism and oxidation, ACACA and ACACB are therapeutic targets for treating obesity and metabolic syndrome disorders.
Physical form
Buffered aqueous solution containing Tris-HCl, pH 8.0, NaCl, glycerol, and DTT. May also contain one or more of the following: EDTA, KCl, imidazole, TWEEN-20.
Preparation Note
Thaw on ice. Upon first thaw, briefly spin tube containing enzyme to recover full content of the tube. Aliquot enzyme into single use aliquots. Store remaining undiluted enzyme in aliquots at -70°C. Note: Enzyme is very sensitive to freeze/thaw cycles.
Other Notes
One unit will cause the carboxylation of 1 picomole of acetyl-CoA per minute at pH 7.4 at 30 deg C.
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Ta pozycja | |||
|---|---|---|---|
| Gene Information human ... ACACB(32) | Gene Information human ... ACACB(32) | Gene Information human ... ACACB(32) | Gene Information human ... ACACA(31) |
| specific activity ≥25 units/μg protein | specific activity - | specific activity - | specific activity ≥20 units/μg protein |
| form solution | form - | form buffered aqueous glycerol solution | form liquid |
| recombinant expressed in Sf9 cells | recombinant - | recombinant - | recombinant expressed in Sf9 cells |
| shipped in dry ice | shipped in dry ice | shipped in wet ice | shipped in dry ice |
| storage temp. −70°C | storage temp. −20°C | storage temp. −20°C | storage temp. −70°C |
Klasa składowania
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
W W Winder et al.
The American journal of physiology, 270(2 Pt 1), E299-E304 (1996-02-01)
Malonyl-CoA, an inhibitor of fatty acid oxidation in skeletal muscle mitochondria, decreases in rat skeletal muscle during exercise or in response to electrical stimulation. Regulation of rat skeletal muscle acetyl-CoA carboxylase (ACC), the enzyme that synthesizes malonyl-CoA, was studied in
Sihao Liu et al.
Nature, 502(7472), 550-554 (2013-10-25)
Food intake increases the activity of hepatic de novo lipogenesis, which mediates the conversion of glucose to fats for storage or use. In mice, this program follows a circadian rhythm that peaks with nocturnal feeding and is repressed by Rev-erbα/β
Lutfi Abu-Elheiga et al.
Proceedings of the National Academy of Sciences of the United States of America, 100(18), 10207-10212 (2003-08-16)
Malonyl-CoA, generated by acetyl-CoA carboxylases ACC1 and ACC2, is a key metabolite in the control of fatty acid synthesis and oxidation in response to dietary changes. ACC2 is associated to the mitochondria, and Acc2-/- mice have a normal lifespan and
Numer pozycji handlu globalnego
| SKU | NUMER GTIN |
|---|---|
| A6861-10UG | 04061833228425 |