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A6664
4-Amidinophenylmethanesulfonyl fluoride hydrochloride
serine protease inhibitor
Synonim(y):
4-Amidinobenzylsulfonyl fluoride hydrochloride, p-APMSF
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Informacje o tej pozycji
Wzór empiryczny (zapis Hilla):
C8H9FN2O2S · HCl
Numer CAS:
Masa cząsteczkowa:
252.69
UNSPSC Code:
12352202
NACRES:
NA.77
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
9083148
assay
≥97% (silver nitrate titration)
form
powder
mp
190-191 ºC
solubility
H2O: 50 mM (Stable when aliquoted at −20°C. Half-life = 6 minutes in pH 7.0 buffer systems.)
storage temp.
−20°C
SMILES string
Cl[H].NC(=N)c1ccc(CS(F)(=O)=O)cc1
InChI
1S/C8H9FN2O2S.ClH/c9-14(12,13)5-6-1-3-7(4-2-6)8(10)11;/h1-4H,5H2,(H3,10,11);1H
InChI key
KHLLRHIUKOJXLL-UHFFFAOYSA-N
General description
4-Amidinophenylmethanesulfonyl fluoride hydrochloride is relatively nontoxic.[1]
Application
4-Amidinophenylmethanesulfonyl fluoride hydrochloride has been used:
- as a component of inhibitor cocktail for whole blood collection and separation of plasma[2]
- as a component of sodium dodecyl sulfate (SDS) sample buffer to prepare whole-cell extract[3]
- as a trypsin inhibitor to measure its inhibition efficiency and to determine the efficacy of the quantum dot fluorescence resonance energy transfer (FRET)-based enzymatic probes[1]
Biochem/physiol Actions
4-Amidinophenylmethanesulfonyl fluoride hydrochloride (p-APMSF) can inhibit the trypsin-like proteinase produced by Fusarium culmorum.[4] It is also capable of blocking bovine Factor Xa, human plasmin, and the human complement proteases, C1r and C1s.
Irreversible inhibitor of serine proteases with lysine or arginine substrate specificities. Effective concentration 10-100 μM.
Irreversible inhibitor of serine proteases with lysine or arginine substrate specificities. Effective concentration 10-100 μM. Frequently used to characterize newly discovered proteases.
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Klasa składowania
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Product Information Sheet
Anja I Pekkarinen et al.
Journal of agricultural and food chemistry, 50(13), 3849-3855 (2002-06-13)
The fungal disease Fusarium head blight occurs on wheat (Triticum spp.) and barley (Hordeum vulgare L.) and is one of the worldwide problems of agriculture. It can be caused by various Fusarium species. We are characterizing the proteinases of F.
Lifang Shi et al.
Analytical chemistry, 79(1), 208-214 (2006-12-30)
The paper describes the development and characterization of analytical properties of quantum dot-based probes for enzymatic activity and for screening enzyme inhibitors. The luminescent probes are based on fluorescence resonance energy transfer (FRET) between luminescent quantum dots that serve as
Yoshihiro Hayashi et al.
Cancer discovery, 8(11), 1438-1457 (2018-08-25)
Myelodysplastic syndromes (MDS) are heterogeneous hematopoietic disorders that are incurable with conventional therapy. Their incidence is increasing with global population aging. Although many genetic, epigenetic, splicing, and metabolic aberrations have been identified in patients with MDS, their clinical features are
Numer pozycji handlu globalnego
| SKU | NUMER GTIN |
|---|---|
| A6664-10MG | 04061833267561 |
| A6664-50MG | 04061833382622 |