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A4477

Anti-phospho-AMPA Receptor, GluR1 Subunit (pSer⁸⁴⁵) antibody produced in rabbit

Name: Anti-phospho-AMPA Receptor, GluR1 Subunit (pSer<SUP>845</SUP>) antibody produced in rabbit
Brand: SIGMA
Price: 2750 PLN

affinity isolated antibody, buffered aqueous glycerol solution

Synonim(y):

Anti-phospho-AMPA Glutamate Receptor 1 (pSer⁸⁴⁵)

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Gabaryty przesyłki	SKU	Dostępność	Cena netto
150 μL		Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności	2750,00 zł

Informacje o tej pozycji

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD04040523

Conjugate:

unconjugated

Clone:

polyclonal

Application:

DB, WB

Citations:

2750,00 zł

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Rekombinowane, niezawierające konserwantów przeciwciało jest dostępne dla Twojego celu. Wypróbuj ZRB04823

Pomoc techniczna

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Właściwości

biological source

rabbit

Quality Level

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous glycerol solution

mol wt

antigen 100 kDa

species reactivity

human, rat

technique(s)

dot blot: 1:1000, western blot: 1:1,000 using rat brain extracts

UniProt accession no.

P42261

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pSer845)

Gene Information

human ... GRIA1(2890)
rat ... Gria1(50592)

Opis

General description

AMPA is a transmembrane receptor for glutamate that regulates synapsis in the central nervous system. It is composed of 4 types of subunits, GluR1, 2, 3, 4.

Rabbit Anti-phospho-AMPA Receptor, GluR1 Subunit (pSer⁸⁴⁵) antibody recognizes human and rat AMPA Receptor, GluR1 subunit (pSer⁸⁴⁵).

Immunogen

synthetic phosphorylated peptide corresponding to a region near serine 845 of rat glutamate receptor subunit GluR1.

Application

Rabbit Anti-phospho-AMPA Receptor, GluR1 Subunit (pSer⁸⁴⁵) antibody can be used for western blot analysis at 1:1,000 using rat brain extracts.

Physical form

Solution in 10 mM HEPES buffer, pH 7.5, containing 150 mM NaCl, 100 μg/ml BSA and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Ta pozycja	A4352	SAB5201088	SAB5201096
Sigma-Aldrich A4477 Anti-phospho-AMPA Receptor, GluR1 Subunit (pSer⁸⁴⁵) antibody produced in rabbit	Sigma-Aldrich A4352 Anti-phospho-AMPA Receptor, GluR1 Subunit (pSer⁸³¹) antibody produced in rabbit	Sigma-Aldrich SAB5201088 Monoclonal Anti-Glua1/Glur1 - Atto 488 antibody produced in mouse	Sigma-Aldrich SAB5201096 Monoclonal Anti-Glua1/Glur1 - Apc antibody produced in mouse
Quality Level 200	Quality Level 200	Quality Level 100	Quality Level 100
biological source rabbit	biological source rabbit	biological source mouse	biological source mouse
antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form purified immunoglobulin	antibody form purified immunoglobulin
conjugate unconjugated	conjugate unconjugated	conjugate Atto 488 conjugate	conjugate Allophycocyanin conjugate
Gene Information human ... GRIA1(2890) rat ... Gria1(50592)	Gene Information human ... GRIA1(2890) rat ... Gria1(50592)	Gene Information rat ... Gria1(50592)	Gene Information rat ... Gria1(50592)
mol wt antigen 100 kDa	mol wt antigen 100 kDa	mol wt antigen predicted mol wt 100 kDa	mol wt antigen predicted mol wt 100 kDa

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Klasa składowania

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Data Sheet - A4477

Instructions

Amygdala levels of the GluA1 subunit of glutamate receptors and its phosphorylation state at serine 845 in the anterior hippocampus are biomarkers of ictal fear but not anxiety.

Rodrigo Bainy Leal et al.

Molecular psychiatry, 25(3), 655-665 (2018-06-09)

Fear is a conscious state caused by exposure to real or imagined threats that trigger stress responses that affect the body and brain, particularly limbic structures. A sub-group of patients with mesial temporal lobe epilepsy related to hippocampus sclerosis (MTLE-HS)

LRRK2 regulates synaptogenesis and dopamine receptor activation through modulation of PKA activity.

Loukia Parisiadou et al.

Nature neuroscience, 17(3), 367-376 (2014-01-28)

Leucine-rich repeat kinase 2 (LRRK2) is enriched in the striatal projection neurons (SPNs). We found that LRRK2 negatively regulates protein kinase A (PKA) activity in the SPNs during synaptogenesis and in response to dopamine receptor Drd1 activation. LRRK2 interacted with

A single high dose of dexamethasone affects the phosphorylation state of glutamate AMPA receptors in the human limbic system.

M W Lopes et al.

Translational psychiatry, 6(12), e986-e986 (2016-12-14)

Glucocorticoids (GC) released during stress response exert feedforward effects in the whole brain, but particularly in the limbic circuits that modulates cognition, emotion and behavior. GC are the most commonly prescribed anti-inflammatory and immunosuppressant medication worldwide and pharmacological GC treatment

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Numer pozycji handlu globalnego

SKU	NUMER GTIN
A4477-100UL	04061835805136
A4477-150UL	04061837829796

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