A3940

1-Aminobenzotriazole

≥98% (TLC), powder, cytochrome P450 inhibitor

• Synonim(y): 1-Benzotriazolamine, ABT
• Wzór empiryczny (zapis Hilla): C₆H₆N₄
• Numer CAS: 1614-12-6
• Masa cząsteczkowa: 134.14
• NACRES: NA.77
• PubChem Substance ID: 24278226
• UNSPSC Code: 12352200
• MDL number: MFCD00132902
• Beilstein/REAXYS Number: 607843
• Assay: ≥98% (TLC)
• Form: powder
• Quality level: 200

Właściwości

• Nazwa produktu: 1-Aminobenzotriazole,
• assay: ≥98% (TLC)
• Quality Level: 200
• form: powder
• greener alternative product score: old score: 93; new score: 46; Find out more about DOZN™ Scoring
• greener alternative product characteristics: Waste Prevention; Safer Solvents and Auxiliaries; Inherently Safer Chemistry for Accident Prevention; Learn more about the Principles of Green Chemistry.
• sustainability: Greener Alternative Product
• mp: 81-84 °C (lit.)
• solubility: ethanol: 49-51 mg/mL, clear, pale yellow to yellow
• greener alternative category: , Re-engineered
• SMILES string: Nn1nnc2ccccc12
• InChI: 1S/C6H6N4/c7-10-6-4-2-1-3-5(6)8-9-10/h1-4H,7H2
• InChI key: JCXKHYLLVKZPKE-UHFFFAOYSA-N
• Gene Information: human ... CYP1A2(1544)

Opis

General description

We are committed to bringing you Greener Alternative Products, which adhere to one of the four categories of Greener Alternatives. This product belongs to category of Re-engineered products, showing key improvements in Green Chemistry Principles “Waste Prevention”, “Safer Solvents and Auxiliaries” and “Inherently Safer Chemistry for Accident Prevention”. Click here to view its DOZN scorecard.

Application

1-Aminobenzotriazole has been used as a cytochrome P450 inhibitor to study the effects of estrogen on H₂O₂-induced premature senescence of vascular smooth muscle cells from old rats It has also been used to study the estrogen receptor-mediated effects of 17β-estradiol.[1]

Biochem/physiol Actions

Suicide inhibitor of cytochrome P450 and chloroperoxidase.

1-Aminobenzotriazole (1-ABT) is used as an in vitro tool in drug discovery. It can differentiate the P450 from non-P450 enzyme systems. 1-ABT exhibits inhibitory action by covalent alteration of the heme prosthetic group in the P450 enzyme.

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Informacja o środkach bezpieczeństwa

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319,H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves