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Merck

A2169

3′-Azido-3′-deoxythymidine

≥98% (HPLC), powder, reverse transcriptase inhibitor

Synonim(y):

AZT, Azidothymidine, ZDV, Zidovudine

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Wybierz wielkość

25 MG

376,00 zł

100 MG

1330,00 zł

250 MG

2150,00 zł

1 G

6850,00 zł

376,00 zł

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Informacje o tej pozycji

Wzór empiryczny (zapis Hilla):
C10H13N5O4
Numer CAS:
30516-87-1
Masa cząsteczkowa:
267.24
NACRES:
NA.77
PubChem Substance ID:
24278143
UNSPSC Code:
12352200
MDL number:
MFCD00006536
Beilstein/REAXYS Number:
3595791
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
200

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Nazwa produktu

3′-Azido-3′-deoxythymidine, ≥98% (HPLC)

InChI

1S/C10H13N5O4/c1-5-3-15(10(18)12-9(5)17)8-2-6(13-14-11)7(4-16)19-8/h3,6-8,16H,2,4H2,1H3,(H,12,17,18)/t6-,7+,8+/m0/s1

SMILES string

CC1=CN([C@H]2C[C@H](N=[N+]=[N-])[C@@H](CO)O2)C(=O)NC1=O

InChI key

HBOMLICNUCNMMY-XLPZGREQSA-N

assay

≥98% (HPLC)

form

powder

mp

113-115 °C (lit.)

solubility

H2O: 50 mg/mL

storage temp.

−20°C

Quality Level

200

Gene Information

human ... HIVE1(3095)
mouse ... Slc29a1(63959)

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Ta pozycja
BP803PHR1292Z1900000
3′-Azido-3′-deoxythymidine ≥98% (HPLC)

Sigma-Aldrich

A2169

3′-Azido-3′-deoxythymidine

Zidovudine British Pharmacopoeia (BP) Reference Standard

BP803

Zidovudine

Zidovudine Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1292

Zidovudine

Zidovudine European Pharmacopoeia (EP) Reference Standard

Z1900000

Zidovudine

assay

≥98% (HPLC)

assay

-

assay

-

assay

-

form

powder

form

solid

form

-

form

-

Quality Level

200

Quality Level

-

Quality Level

300

Quality Level

-

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

H2O: 50 mg/mL

solubility

-

solubility

-

solubility

-

mp

113-115 °C (lit.)

mp

113-115 °C (lit.)

mp

113-115 °C (lit.)

mp

113-115 °C (lit.)

Application

3′-Azido-3′-deoxythymidine has been used as the reverse transcriptase inhibitor to inhibit the viral genome integration and as an antimicrobial agent to evaluate its anti-Salmonella activity.

Biochem/physiol Actions

Azidothymidine (AZT), a thymidine analogue, is a reverse transcriptase inhibitor against the HIV-1 virus. Azidothymidine has been shown to decrease CRISPR-mediated homology-directed repair (HDR) efficiency.
Reverse transcriptase inhibitor active against HIV-1 virus.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
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pictograms

Health hazard
GHS08

signalword

Warning

hcodes

H341,H351

Hazard Classifications

Carc. 2 - Muta. 2

Klasa składowania

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

Wybierz jedną z najnowszych wersji:

Certyfikaty analizy (CoA)

Lot/Batch Number
MKCW0371
MKCW5948
MKCS1355
MKCR8766
MKCQ4508

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Masz już ten produkt?

Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Protein overexpression following lentiviral infection of primary mature neutrophils is due to pseudotransduction
Geering B, et al.
Journal of Immunological Methods, 373(1-2), 209-218 (2011)
Primary role of type I interferons for the induction of functionally optimal antigen-specific CD8+ T cells in HIV infection.
Cabral-Piccin, et al.
EBioMedicine, 91, 104557-104557 (2023)
Zahidul Khan et al.
Neuro-oncology, 12(6), 549-558 (2010-02-16)
The prognosis for malignant gliomas remains poor, and new treatments are urgently needed. Targeted suicide gene therapy exploits the enzymatic conversion of a prodrug, such as a nucleoside analog, into a cytotoxic compound. Although this therapeutic strategy has been considered
In vitro activities of nucleoside analog antiviral agents against salmonellae.
Sperber S J, et al.
Antimicrobial Agents and Chemotherapy, 37(1), 106-110 (1993)
Marla E Tharp et al.
Nature communications, 11(1), 330-330 (2020-01-18)
Female reproductive success critically depends on the size and quality of a finite ovarian reserve. Paradoxically, mammals eliminate up to 80% of the initial oocyte pool through the enigmatic process of fetal oocyte attrition (FOA). Here, we interrogate the striking
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Questions

  1. For the use of this product in cell culture, what would be the best conditions for making stock solutions. Solvent, concentration, filtering, storage temp etc.?

    1 answer

    1. Unfortunately, this product has not been tested for cell culture applications. This compound is soluble at 50 mg/mL in water. For use in cell culture, the stock solution should be filter sterilized. Syringe filter product SLGVR33RS may be of interest. The pharmaceutical literature suggests that the stock solution is stable for 1 day at room temperature and 2 days if refrigerated.

      See the link below to a publication (page 3) regarding the stability of AZT in solution:
      https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/019910s041lbl.pdf

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