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Merck

A2093

Aspirin

meets USP testing specifications

Synonim(y):

Acetylsalicylic acid, 2-Acetoxybenzoic acid, O-Acetylsalicylic acid, ASA, Aspirin

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100 G

361,00 zł

500 G

1380,00 zł

361,00 zł

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Informacje o tej pozycji

Wzór liniowy:
2-(CH3CO2)C6H4CO2H
Numer CAS:
50-78-2
Masa cząsteczkowa:
180.16
UNSPSC Code:
12352106
NACRES:
NA.21
PubChem Substance ID:
24890623
EC Number:
200-064-1
Beilstein/REAXYS Number:
779271
MDL number:
MFCD00002430

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InChI key

BSYNRYMUTXBXSQ-UHFFFAOYSA-N

InChI

1S/C9H8O4/c1-6(10)13-8-5-3-2-4-7(8)9(11)12/h2-5H,1H3,(H,11,12)

SMILES string

CC(=O)Oc1ccccc1C(O)=O

agency

USP/NF, meets USP testing specifications

form

powder or crystals

Quality Level

200

Gene Information

human ... ITGA2B(3674), PTGS1(5742), PTGS2(5743)

application(s)

pharmaceutical (small molecule)

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Ta pozycja
A31601044006BP617
Aspirin meets USP testing specifications

Sigma-Aldrich

A2093

Aspirin

Acetylsalicylic acid analytical standard

Sigma-Aldrich

A3160

Acetylsalicylic acid

Aspirin United States Pharmacopeia (USP) Reference Standard

USP

1044006

Aspirin

Aspirin British Pharmacopoeia (BP) Reference Standard

BP617

Aspirin

Gene Information

human ... ITGA2B(3674), PTGS1(5742), PTGS2(5743)

Gene Information

human ... ITGA2B(3674), PTGS1(5742), PTGS2(5743)

Gene Information

human ... PTGS1(5742), PTGS2(5743)

Gene Information

human ... PTGS1(5742), PTGS2(5743)

Quality Level

200

Quality Level

200

Quality Level

-

Quality Level

-

form

powder or crystals

form

powder

form

-

form

crystalline

mp

134-136 °C (lit.)

mp

134-136 °C (lit.)

mp

134-136 °C (lit.)

mp

134-136 °C (lit.)

agency

USP/NF

agency

-

agency

-

agency

-

application(s)

pharmaceutical (small molecule)

application(s)

forensics and toxicology
pharmaceutical
veterinary

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical
pharmaceutical small molecule

General description

Aspirin (acetylsalicylic acid) is a nonsteroidal anti-inflammatory drug.[1][2] It occurs as white crystalline powder[2] and is derived from salicylic acid.[2]

Application

Aspirin has been used:
  • as a stabilizer for blood during 13,14-dihydro-15-keto-prostaglandin F2α (PGFM) measurement[3]
  • to evaluate cell viability of BV-2 microglial cell line[4]
  • in morphogenesis assay[5]

Biochem/physiol Actions

Aspirin is an analgesic and antipyretic agent used in the treatment of fever and pain as in arthritis.[6] It is also associated with cardiovascular diseases.[6]
Blocks the production of prostaglandins by inhibiting cyclooxygenase (prostaglandin H synthase), with greater selectivity toward the COX-1 isoform. The antithrombotic effect is due to the inhibition of COX-1 in platelets that blocks thromboxane production and platelet aggregation. Chemopreventive against colorectal and other solid tumors.
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pictograms

Exclamation mark
GHS07

signalword

Warning

Klasa składowania

11 - Combustible Solids

flash_point_f

482.0 °F

flash_point_c

250 °C

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 3

hcodes

H302,H412

Wybierz jedną z najnowszych wersji:

Certyfikaty analizy (CoA)

Lot/Batch Number
MKCZ7871
MKCW1182
0000237091
0000216819
0000216819

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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Relationship between endotoxin and prostaglandin (PGE2 and PGFM) concentrations and ovarian function in dairy cows with puerperal endometritis
Mateus L, et al.
Animal Reproduction Science (2003)
Acetylsalicylic acid enhances the anti-inflammatory effect of fluoxetine through inhibition of NF-kB, p38-MAPK and ERK1/2 activation in lipopolysaccharide-induced BV-2 microglia cells
Yang JM, et al.
Neuroscience, 275, 296-394 (2014)
Concise Clinical Pharmacology (2007)
The 100 Most Important Chemical Compounds: A Reference Guide (2011)
Henry's Clinical Diagnosis and Management by Laboratory Methods E-book (2011)
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Questions

1–3 of 3 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. How to dissolve Aspirin and minimize concentration for storage?

    1 answer

    1. This compound is soluble in ethanol at 50 mg/mL, in water at 3 mg/mL, and in 37 °C water at 10 mg/mL. Acetylsalicylic acid is not stable in aqueous solutions and will readily hydrolyze to salicylic acid. Minimal concentration and solution stability in ethanol have not been established.

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