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Merck

A1976

Sigma-Aldrich

Anti-Amyloid Peptide β, Cleavage Site 42 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonim(y):

Anti-Aβ 42

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About This Item

Numer MDL:
Kod UNSPSC:
12352203
NACRES:
NA.41

pochodzenie biologiczne

rabbit

Poziom jakości

białko sprzężone

unconjugated

forma przeciwciała

affinity isolated antibody

rodzaj przeciwciała

primary antibodies

klon

polyclonal

Postać

buffered aqueous solution

masa cząsteczkowa

antigen 4 kDa

reaktywność gatunkowa

rat, human, mouse

opakowanie

antibody small pack of 25 μg

metody

dot blot: 0.05-1 μg/mL
immunoblotting: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
indirect ELISA: 1:200
radioimmunoassay: 1:200

numer dostępu UniProt

Warunki transportu

dry ice

temp. przechowywania

−70°C

docelowa modyfikacja potranslacyjna

proteolytically cleaved (Ala42)

informacje o genach

human ... APP(351)
mouse ... App(11820)
rat ... App(54226)

Opis ogólny

Proteolytic cleavage of the amyloid precursor protein (APP) produces the small fragment amyloid β peptide. Cleavage of APP occurs mostly at residue 40 but to a lesser extent residue 42. Aggregates of amyloid β peptide are found deposited in the brains of Alzheimer′s patients.
Rabbit anti-amyloid peptide β, cleavage site 42 (Aβ42) antibody binds to human, mouse and rat Aβ42.

Immunogen

synthetic peptide of approximately 10 amino acid residues at the C-terminus of Aβ42.

Zastosowanie

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (1 paper)
Rabbit anti-Aβ42 is suitable for use in immunoblot, immunohistochemistry, immunoprecipitation, RIA, ELISA and dot blot applications.

Postać fizyczna

Solution in phosphate buffer, pH 7.4, containing approximately 25 μg of antibody.

Oświadczenie o zrzeczeniu się odpowiedzialności

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Kod klasy składowania

10 - Combustible liquids

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Środki ochrony indywidualnej

Eyeshields, Gloves


Certyfikaty analizy (CoA)

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Masz już ten produkt?

Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Ukjin Kim et al.
Frontiers in pharmacology, 10, 1517-1517 (2020-02-06)
The United States Food and Drug Administration-approved antipsychotic drug, pimozide, has anticancer activities. However, the role of reactive oxygen species (ROS) in its effect on prostate cancer is not well-known. We examined cell proliferation, colony formation, migration, ROS production, and
Kathlyn J Gan et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 40(42), 8088-8102 (2020-09-26)
Emerging evidence supports roles for secreted extracellular matrix proteins in boosting synaptogenesis, synaptic transmission, and synaptic plasticity. SPARCL1 (also known as Hevin), a secreted non-neuronal protein, was reported to increase synaptogenesis by simultaneously binding to presynaptic neurexin-1α and to postsynaptic
Bao-Xi Qu et al.
Journal of the neurological sciences, 260(1-2), 204-213 (2007-06-19)
Abeta42 peptide aggregation and deposition is an important component of the neuropathology of Alzheimer's disease (AD). Gene-gun mediated gene vaccination targeting Abeta42 is a potential method to prevent and treat AD. APPswe/PS1DeltaE9 transgenic (Tg) mice were immunized with an Abeta42

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