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Dokumenty

422R-1

Sigma-Aldrich

PHOX2B (EP312) Rabbit Monoclonal Primary Antibody

Synonim(y):

Paired-like Homeobox 2B

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About This Item

Kod UNSPSC:
12352203

pochodzenie biologiczne

rabbit

Poziom jakości

100
500

białko sprzężone

unconjugated

forma przeciwciała

culture supernatant

rodzaj przeciwciała

primary antibodies

klon

EP312, monoclonal

opis

For In Vitro Diagnostic Use in Select Regions

Postać

buffered aqueous solution

reaktywność gatunkowa

human

opakowanie

vial of 0.1 mL concentrate (422R-14)
vial of 0.1 mL concentrate Research Use Only (422R-14-RUO)
vial of 0.5 mL concentrate (422R-15)
vial of 1.0 mL concentrate (422R-16)
vial of 1.0 mL concentrate Research Use Only (422R-16-RUO)
vial of 1.0 mL pre-dilute Research Use Only (422R-17-RUO)
vial of 1.0 mL pre-dilute ready-to-use (422R-17)
vial of 7.0 mL pre-dilute ready-to-use (422R-18)
vial of 7.0 mL pre-dilute ready-to-use Research Use Only (422R-18-RUO)

producent / nazwa handlowa

Cell Marque™

metody

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100 (concentrated)

izotyp

IgG

kontrola

neuroblastoma

Warunki transportu

wet ice

temp. przechowywania

2-8°C

wizualizacja

nuclear

informacje o genach

human ... PHOX2B(8929)

Powiązane kategorie

Opis ogólny

Paired-like homeobox 2B (PHOX2B) is a transcription factor located on chromosome 4p13 which is crucial to the formation of autonomic ganglia in the autonomic nervous system (ANS). PHOX2B gene is strictly expressed in neural crest derivatives committed to the noradrenergic phenotype. The PHOX2B gene encodes a paired-like homeo-domain transcription factor with an extra-axial expression pattern restricted to the ANS. Neuroblasts of peripheral neuroblastic tumors are derived from the sympathoadrenal lineage, a division of the ANS. PHOX2B has been observed in peripheral neuroblastic tumors, neuroblastomas, paragangliomas, ganglioneuroblastomas, ganglioneuromas and pheochromocytomas. PHOX2B has been reported to be negative in other small round blue cell tumors.

Jakość


IVD
IVD
IVD
RUO

Powiązanie

PHOX2B Positive Control Slides, Product No. 422S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Postać fizyczna

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Uwaga dotycząca przygotowania

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Inne uwagi

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Informacje prawne

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Kod klasy składowania

12 - Non Combustible Liquids

Klasa zagrożenia wodnego (WGK)

WGK 2

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Certyfikaty analizy (CoA)

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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

A Pattyn et al.
Nature, 399(6734), 366-370 (1999-06-09)
The sympathetic, parasympathetic and enteric ganglia are the main components of the peripheral autonomic nervous system, and are all derived from the neural crest. The factors needed for these structures to develop include the transcription factor Mash1, the glial-derived neurotrophic
Daisuke Nonaka et al.
The American journal of surgical pathology, 37(8), 1236-1241 (2013-05-30)
Autonomic neurons and chromaffin cells, which constitute the autonomic nervous system, are derived from a common progenitor from the neural crest, and its development is controlled by a network of transcription factors, including the master regulator, Phox2b, and its downstream
L Longo et al.
International journal of oncology, 33(5), 985-991 (2008-10-25)
The detection of PHOX2B mutations in a small proportion of patients affected with either familial or sporadic neuroblastoma (NB), has arisen interest on the possible pathogenic role of this gene in the disease determination. In this light, we have carried
Franck Bielle et al.
The American journal of surgical pathology, 36(8), 1141-1149 (2012-07-14)
Peripheral neuroblastic tumors are the most commonly occurring extracranial tumors in children. Although a reliable diagnosis is achievable in the majority of cases, diagnosis of a minority of peripheral neuroblastic tumor cases (especially undifferentiated neuroblastoma) poses a challenge compared with
Franck Bourdeaut et al.
Cancer letters, 228(1-2), 51-58 (2005-06-14)
Hereditary predisposition to neuroblastoma accounts for less than 5% of neuroblastomas and is probably heterogeneous. Recently, a predisposition gene has been mapped to 16p12-p13, but has not yet been identified. Occurrence of neuroblastoma in association with congenital central hypoventilation and

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