368R-7
T-bet (MRQ-46) Rabbit Monoclonal Antibody
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About This Item
Kod UNSPSC:
12352203
NACRES:
NA.41
Produkt 368R-7 nie jest obecnie dostępny w sprzedaży w Twoim kraju Skontaktuj się z zespołem ds. pomocy technicznej
Polecane produkty
pochodzenie biologiczne
rabbit
Poziom jakości
100
500
białko sprzężone
unconjugated
forma przeciwciała
culture supernatant
rodzaj przeciwciała
primary antibodies
klon
MRQ-46, monoclonal
opis
For In Vitro Diagnostic Use in Select Regions (See Chart)
Formularz
buffered aqueous solution
reaktywność gatunkowa
human
opakowanie
vial of 0.1 mL concentrate (368R-74)
vial of 0.5 mL concentrate (368R-75)
bottle of 1.0 mL predilute (368R-77)
vial of 1.0 mL concentrate (368R-76)
bottle of 7.0 mL predilute (368R-78)
producent / nazwa handlowa
Cell Marque®
metody
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500
izotyp
IgG1
kontrola
tonsil
Warunki transportu
wet ice
temp. przechowywania
2-8°C
wizualizacja
nuclear
informacje o genach
human ... TBX21(30009)
Powiązane kategorie
Opis ogólny
T-bet, a T-box transcription factor, is expressed in CD4+ T-lymphocytes committed to T-helper (Th)1 T-cell development from naïve T-helper precursor cells (Thp) and redirects Th2 T-cells to Th1 development. Anti-T-bet is a marker of mature T-cells and is expressed at very low levels in Thp cells and is absent in precursor T-lymphoblastic leukemia/lymphoma cells. Scattered small lymphocytes in the interfollicular T-cell zone of reactive lymphoid tissue, including tonsil, lymph node, and spleen exhibited nuclear staining for anti-T-bet, with no anti-T-bet staining observed in germinal centers or mantle or marginal zones. T-bet is expressed in a significant subset of B-cell lymphoproliferative disorders, particularly at an early stage of B-cell development (precursor B-cell lymphoblastic leukemia/lymphoblastic lymphoma), and B-cell neoplasms derived from mature B-cells, including CLL/SLL, marginal zone lymphoma, and hairy cell leukemia. In contrast, B-cell neoplasms derived from pre-germinal center or germinal center B-cells, including mantle cell lymphoma, follicular lymphoma, diffuse large B-cell lymphoma, and Burkitt lymphoma are negative for anti-T-bet. Therefore, anti-T-bet should serve as a useful marker for the diagnosis and subtyping of B-cell and T-cell lymphoproliferative disorders.[1][2][3][4][5][6][7]
Jakość
 IVD |  IVD |  IVD |  RUO |
Powiązanie
T-bet Positive Control Slides, Product No. 368S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
Postać fizyczna
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
Uwaga dotycząca przygotowania
Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.
Inne uwagi
For Technical Service please contact: 800-665-7284 or email: [email protected]
Informacje prawne
Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
David M Dorfman et al.
American journal of clinical pathology, 122(2), 292-297 (2004-08-25)
T-bet, a T-box transcription factor, is expressed in CD4+ T lymphocytes committed to Th1 T-cell development and in a subset of T-cell non-Hodgkin lymphomas. Recent evidence indicates that T-bet also is expressed in B lymphocytes and might participate in immunoglobulin
S J Szabo et al.
Cell, 100(6), 655-669 (2000-04-13)
Naive T helper cells differentiate into two subsets, Th1 and Th2, each with distinct functions and cytokine profiles. Here, we report the isolation of T-bet, a Th1-specific T box transcription factor that controls the expression of the hallmark Th1 cytokine
Cigdem Atayar et al.
The American journal of pathology, 166(1), 127-134 (2005-01-06)
Since Hodgkin and Reed-Sternberg (HRS) cells of Hodgkin lymphoma (HL) generally have immunoglobulin gene rearrangements, they are considered to be of B-cell origin. One of the characteristics of HRS cells is a prominent production of various cytokines and chemokines. Cytokine
Akira Harashima et al.
Leukemia research, 29(7), 841-848 (2005-06-02)
A number of transcription factors (TFs) have been reported that play crucial roles in hematopoiesis. However, only little is known about how these factors are involved in the mechanisms of hematopoietic development and lineage commitment. To investigate the roles of
Korinna Jöhrens et al.
The American journal of surgical pathology, 31(8), 1181-1185 (2007-08-02)
Diagnosis of minimal infiltration by hairy cell leukemia (HCL) cells in bone marrow trephines is challenging as its differentiation from interstitially distributed infiltrates of reactive B cells and small B-cell lymphomas other than HCL is difficult or impossible. The diagnostic
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