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04555
Trypanothione trifluoroacetate salt
≥98% (HPLC)
Synonim(y):
N1,N8-Bis(glutathionyl)spermidine disulfide
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Informacje o tej pozycji
Wzór empiryczny (zapis Hilla):
C27H47N9O10S2 · xC2HF3O2
Numer CAS:
Masa cząsteczkowa:
721.85 (free base basis)
UNSPSC Code:
12352204
NACRES:
NA.32
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
3645155
Assay:
≥98% (HPLC)
Form:
powder or crystals
assay
≥98% (HPLC)
form
powder or crystals
solubility
water: soluble 1 g/L
storage temp.
−20°C
SMILES string
OC(=O)C(F)(F)F.N[C@@H](CCC(=O)N[C@H]1CSSCC(NC(=O)CC[C@H](N)C(O)=O)C(=O)NCC(=O)NCCCNCCCCNC(=O)CNC1=O)C(O)=O
InChI
1S/C27H47N9O10S2.C2HF3O2/c28-16(26(43)44)4-6-20(37)35-18-14-47-48-15-19(36-21(38)7-5-17(29)27(45)46)25(42)34-13-23(40)32-11-3-9-30-8-1-2-10-31-22(39)12-33-24(18)41;3-2(4,5)1(6)7/h16-19,30H,1-15,28-29H2,(H,31,39)(H,32,40)(H,33,41)(H,34,42)(H,35,37)(H,36,38)(H,43,44)(H,45,46);(H,6,7)/t16-,17-,18-,19?;/m0./s1
InChI key
BLTBWJNAZIKNTL-QZBRSAASSA-N
Biochem/physiol Actions
Metabolite in the glutathione metabolism. A novel bis(glutathionyl)spermidine cofactor for glutathione reductase in trypanosomatids[1].
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
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Klasa składowania
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
C Dumas et al.
The EMBO journal, 16(10), 2590-2598 (1997-05-15)
Parasitic protozoa belonging to the order Kinetoplastida contain trypanothione as their major thiol. Trypanothione reductase (TR), the enzyme responsible for maintaining trypanothione in its reduced form, is thought to be central to the redox defence systems of trypanosomatids. To investigate
A H Fairlamb et al.
Science (New York, N.Y.), 227(4693), 1485-1487 (1985-03-22)
Glutathione reductase from trypanosomes and leishmanias, unlike glutathione reductase from other organisms, requires an unusual low molecular weight cofactor for activity. The cofactor was purified from the insect trypanosomatid Crithidia fasciculata and identified as a novel glutathione-spermidine conjugate, N1,N8-bis(L-gamma-glutamyl-L-hemicystinyl-glycyl)spermidine, for
R Mukhopadhyay et al.
Proceedings of the National Academy of Sciences of the United States of America, 93(19), 10383-10387 (1996-09-17)
Leishmania resistant to arsenicals and antimonials extrude arsenite. Previous results of arsenite uptake into plasma membrane-enriched vesicles suggested that the transported species is a thiol adduct of arsenite. In this paper, we demonstrate that promastigotes of arsenite-resistant Leishmania tarentolae have
Numer pozycji handlu globalnego
| SKU | NUMER GTIN |
|---|---|
| 268992-25G | 04061837580949 |
| 268992-5G | 04061826134894 |
| 04555-1MG | 04061838633439 |
| 04555-5MG | 04061831579697 |