75965
Oxytetracycline dihydrate
≥98.0% (NT)
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Informacje o tej pozycji
Wzór empiryczny (zapis Hilla):
C22H24N2O9 · 2H2O
Numer CAS:
Masa cząsteczkowa:
496.46
UNSPSC Code:
51101500
MDL number:
Beilstein/REAXYS Number:
2714587
Pomoc techniczna
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Pozwól nam pomócassay
≥98.0% (NT)
optical activity
[α]20/D −195±3°, c = 1% in 0.1 M HCl
mp
182-186 °C (dec.)
application(s)
agriculture
environmental
mode of action
protein synthesis | interferes
SMILES string
[H]O[H].[H]O[H].CN(C)[C@H]1C2[C@@H](O)C3C(=C(O)[C@]2(O)C(=O)C(C(N)=O)=C1O)C(=O)c4c(O)cccc4[C@@]3(C)O
General description
Chemical structure: tetracycline
Biochem/physiol Actions
Antibiotic produced by Streptomyces rimosus.
Mode of Action: Inhibits protein synthesis (elongation) by preventing binding of aminoacyl-tRNA to the 30S subunit.
Antimicrobial spectrum: Gram-negative and Gram-positive bacteria.
Mode of Resistance: Active efflux, ribosome protection, tetracycline inactivation.
Mode of Action: Inhibits protein synthesis (elongation) by preventing binding of aminoacyl-tRNA to the 30S subunit.
Antimicrobial spectrum: Gram-negative and Gram-positive bacteria.
Mode of Resistance: Active efflux, ribosome protection, tetracycline inactivation.
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
J. Drew, F.E. Hahn et al.
Topics in Infectious Diseases, 217-217 null
N T Antunes et al.
Antimicrobial agents and chemotherapy, 51(9), 3452-3454 (2007-07-20)
MICs were determined for 15 antimicrobial agents against 37 Mycoplasma putrefaciens isolates. The most effective antimicrobial drug classes were the fluoroquinolones, the tetracyclines, the lincosamide lincomycin, and the macrolides. The susceptibility profile of the isolates correlated with the geographic origin.
Jody L Floyd et al.
Antimicrobial agents and chemotherapy, 54(12), 5406-5412 (2010-09-22)
A multidrug efflux pump designated LmrS (lincomycin resistance protein of Staphylococcus aureus), belonging to the major facilitator superfamily (MFS) of transporters, was cloned, and the role of LmrS in antimicrobial efflux was evaluated. The highest relative increase in MIC, 16-fold