According to the literature, the GT1-7 cell line expresses both GLP-1 and GHSR-1a receptors.
SCC116
GT1-7 Mouse Hypothalamic GnRH Neuronal Cell Line
Mouse
Synonim(y):
GT1-7 hypothalamic cell line, GT1-7 neural cell line
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| Gabaryty przesyłki | SKU | Dostępność | Cena netto |
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Informacje o tej pozycji
UNSPSC Code:
41106514
NACRES:
NA.81
eCl@ss:
32011203
Biological source:
mouse
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Pozwól nam pomócNazwa produktu
GT1-7 Mouse Hypothalamic GnRH Neuronal Cell Line, GT1-7 cells can be used as an in vitro model of GnRH-secreting neurons of the hypothalamus.
biological source
mouse
Quality Segment
technique(s)
cell based assay: suitable, cell culture | mammalian: suitable
shipped in
ambient
storage temp.
-140 to -196°C
General description
GT1-7 is an immortalized mature mouse hypothalamic GnRH neuronal cell line. Immortalized GnRH neurons were generated by introducing a transgene containing the promotor region of the GnRH gene coupled to the coding region of the SV40 T-antigen oncogene into transgenic mice1. The resulting anterior hypothalamic tumors were removed from one of the mice and the cells dissociated and cloned. GT1-7 is a clonal line of mature differentiated GnRH neurons that exhibit high levels of Gnrh1 mRNA and secrete GnRH in response to depolarization.
Gonadotrophin-releasing hormone (GnRH) is a neuropeptide that is synthesized and released from GnRH neurons within the hypothalamus and is required for normal reproductive development and function. The scarcity and scattered distribution of GnRH neurons in the rostral hypothalamus make the biological study of the cells difficult.
Application
Research Category
Endocrine
Neuroscience
Endocrine
Neuroscience
Subject to local law, this product is intended to be sold for internal in vitro research use only subject to terms and conditions found here: www.sigmaaldrich.com/restrictedcelluse. This product may not be: re-engineered or copied; used to make derivatives, modifications or functional equivalents; used to obtain patents or other IP claiming use of the product; used to develop, test, or manufacturer a commercial product; used as a component in a commercial product; resold or licensed; used in any clinical applications or trials; or used in humans. A license or limited commercial use agreement is required for use by any for-profit entity, use in services, and use in sponsored academic research. For information regarding any such use, please contact [email protected].
Biochem/physiol Actions
Neural Lineage Cells
Preparation Note
Store in liquid nitrogen. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.
Analysis Note
• Each vial contains ≥ 1X106 viable cells.
• Cells tested negative for infectious diseases by a Mouse/Rat Comprehensive CLEAR panel PCR panel by Charles River Animal Diagnostic Services.
• Cells tested negative for mycoplasma contamination.
• Cells tested negative for infectious diseases by a Mouse/Rat Comprehensive CLEAR panel PCR panel by Charles River Animal Diagnostic Services.
• Cells tested negative for mycoplasma contamination.
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Klasa składowania
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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Powiązane treści
Z Liposits et al.
Endocrinology, 129(3), 1575-1583 (1991-09-01)
An immortalized LHRH cell line has recently been developed by genetically targeting these neurons for tumorigenesis. One of the subclones, the GT1-7 cells, was characterized at both the light and electron microscopic levels to study the cellular and subcellular organization
W C Wetsel et al.
Proceedings of the National Academy of Sciences of the United States of America, 89(9), 4149-4153 (1992-05-01)
Mammalian reproduction is dependent upon intermittent delivery of luteinizing hormone-releasing hormone (LHRH) to the anterior pituitary. This mode of secretion is required to sensitize maximally the gonadotrophs to LHRH stimulation and to regulate gonadotropin gene expression. While LHRH secretion is
W C Wetsel et al.
Endocrinology, 129(3), 1584-1595 (1991-09-01)
An immortalized hypothalamic neuronal cell line was recently developed by genetically targeting the expression of the simian virus-40 large T-antigen in LHRH neurons. These GT1 cells were subcloned to GT1-1, GT1-3, and GT1-7 cells, and they have been shown to
Numer pozycji handlu globalnego
| SKU | NUMER GTIN |
|---|---|
| SCC116 | 04054839165849 |
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Hi Sir, Does it include GLP-1 and GHSR-1A receptors?
1 answer-
Helpful?
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