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ABS236

Anti-Cytochrome P450 (scc) Antibody, a.a. 509-526

Name: Anti-Cytochrome P450 (scc) Antibody, a.a. 509-526
Brand: MM
Price: 1360 PLN
Availability: InStock

from rabbit, purified by affinity chromatography

Synonim(y):

Cholesterol side-chain cleavage enzyme, mitochondrial, CYPXIA1, Cholesterol desmolase, Cytochrome P450 11A1, Cytochrome P450(scc)

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Gabaryty przesyłki	SKU	Dostępność	Cena netto
100 μg		Przewidywany termin wysyłki21 maja 2026zKuehne + Nagel Sp. z o.o.	1360,00 zł

Informacje o tej pozycji

UNSPSC Code:

12352203

NACRES:

NA.41

eCl@ss:

32160702

Conjugate:

unconjugated

Clone:

polyclonal

Application:

IHC, WB

Citations:

1360,00 zł

Przewidywany termin wysyłki21 maja 2026Szczegóły

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Pomoc techniczna

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Pozwól nam pomóc

Właściwości

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

rat

technique(s)

immunohistochemistry: suitable (paraffin), western blot: suitable

NCBI accession no.

NP_058982

UniProt accession no.

P14137

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

rat ... Cyp11A1(29680)

Opis

General description

As a member of the cytochrome P450 family, Cytochrome P450 Side Chain Cleavage Enzyme (scc) catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone during the first step of steroid biosynthesis. It is expressed in certain organs, such as ovaries, adrenal glands, and testis. Deficiency in CYP11A1 is commonly associated with adrenal insufficiency, and with variable degrees of disorder of sex development (DSD).

~52 kDa observed. On higher percentage gels and longer exposures, 8 kDa cleavage product can be detected.

Immunogen

KLH-conjugated linear peptide corresponding to the C-terminus of rat Cytochrome P450 (scc), a.a. 509-526.

Application

Immunohistochemistry Analysis: A 1:4,000-8,000 dilution from a representative lot detected Cytochrome P450 (scc) in rat adrenal gland and rat testis tissue.

This Cytochrome P450 (scc) antibody is validated for use in WB & IHC for the detection of the Cytochrome P450 (scc) protein.

Biochem/physiol Actions

This antibody recognizes the C-terminus of Cytochrome P450 (scc), a.a. 509-526.

Analysis Note

Control
Rat adrenal tissue lysate

Evaluated by Western Blot in rat adrenal tissue lysate.

Western Blot Analysis: 0.02 µg/mL of this antibody detected Cytochrome P450 (scc) in 10 µg of rat adrenal tissue lysate.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Replaces: AB1294

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Ta pozycja	MABS502	SAB4500606	SAB4500609
Sigma-Aldrich ABS236 Anti-Cytochrome P450 (scc) Antibody, a.a. 509-526	Sigma-Aldrich MABS502 Anti-CYP11B1 Antibody, clone 80-7	Sigma-Aldrich SAB4500606 Anti-Cytochrome P450 19A1 antibody produced in rabbit	Sigma-Aldrich SAB4500609 Anti-Cytochrome P450 21A2 antibody produced in rabbit
biological source rabbit	biological source rat	biological source rabbit	biological source rabbit
antibody form affinity isolated antibody	antibody form purified antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level -
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
UniProt accession no. P14137	UniProt accession no. P15538	UniProt accession no. P11511	UniProt accession no. P08686
technique(s) immunohistochemistry: suitable (paraffin), western blot: suitable	technique(s) immunohistochemistry: suitable, western blot: suitable	technique(s) ELISA: 1:20000, immunofluorescence: 1:100-1:500, immunohistochemistry: 1:50-1:100, western blot: 1:500-1:1000	technique(s) ELISA: 1:20000, western blot: 1:500-1:1000

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Klasa składowania

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Odwiedź Bibliotekę dokumentów

MCL1 is a key regulator of steroidogenesis in mouse Leydig cells.

Li Guang-Yu et al.

Molecular reproduction and development, 83(3), 226-235 (2016-03-21)

Myeloid cell leukemia-1 (MCL1), an anti-apoptotic member of the BCL2 family, is expressed abundantly in the testis. Previous characterization revealed that MCL1 is expressed exclusively in the Leydig cells in the mouse testis, yet what it does in these cells

Age-dependent effects of Armc5 haploinsufficiency on adrenocortical function.

A Berthon et al.

Human molecular genetics, 26(18), 3495-3507 (2017-09-16)

Inactivating mutations in the Armadillo repeat-containing 5 (ARMC5) gene have recently been discovered in primary macronodular adrenal hyperplasia (PMAH), a cause of Cushing syndrome. Biallelic ARMC5 inactivation in PMAH suggested that ARMC5 may have tumor suppressor functions in the adrenal

Inhibition of Cytochrome P450 Side-Chain Cleavage Attenuates the Development of Mechanical Allodynia by Reducing Spinal D-Serine Production in a Murine Model of Neuropathic Pain.

Sheu-Ran Choi et al.

Frontiers in pharmacology, 10, 1439-1439 (2019-12-24)

Research indicates that neurosteroids are locally synthesized in the central nervous system and play an important modulatory role in nociception. While the neurosteroidogenic enzyme, cytochrome P450 side-chain cleavage enzyme (P450scc), is the initiating enzyme of steroidogenesis, P450scc has not been

Numer pozycji handlu globalnego

SKU	NUMER GTIN
ABS236	04053252847738

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