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ABE198

Sigma-Aldrich

Anti-Sirt5 Antibody

from rabbit, purified by affinity chromatography

Synonim(y):

NAD-dependent deacetylase sirtuin-5, SIR2-like protein 5

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About This Item

Kod UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

pochodzenie biologiczne

rabbit

Poziom jakości

100

forma przeciwciała

affinity isolated antibody

rodzaj przeciwciała

primary antibodies

klon

polyclonal

oczyszczone przez

affinity chromatography

reaktywność gatunkowa

rat, human

reaktywność gatunkowa (przewidywana na podstawie homologii)

chimpanzee (based on 100% sequence homology), rhesus macaque (based on 100% sequence homology)

metody

immunohistochemistry: suitable
western blot: suitable

numer dostępu NCBI

NP_036373

numer dostępu UniProt

Q9NXA8

Warunki transportu

wet ice

docelowa modyfikacja potranslacyjna

unmodified

informacje o genach

human ... SIRT5(23408)

Opis ogólny

Sirtuin (SIRT5) is known as a nicotinamide adenine dinucleotide- dependent deacetylase that is a member of the silent information regulator 2 (Sir2) family of proteins that is important in aging, metabolism and disease. SIRT5 is expressed in a variety of tissues. Two different isoform have been described. Isoform 1 is reported to be express in the mitochondria and cytoplasm while isoform 2 appears to be localized to the mitochondria only. SIRT5 has also been linked to many primate-specific functions. SIRT5 has recently been implicated as having a role in adaptation to fasting, caloric restriction and high protein diets.

Immunogen

KLH-conjugated linear peptide corresponding to human Sirt5.

Zastosowanie

Immunohistochemistry Analysis: 1:500 dilution of a representative lot of this antibody detected Sirt5 in convoluted tubules of normal rat kidney tissue.
Use Anti-Sirt5 Antibody (Rabbit Polyclonal Antibody) validated in WB, IHC to detect Sirt5 also known as NAD-dependent deacetylase sirtuin-5, SIR2-like protein 5.

Jakość

Evaluated by Western Blot in HeLa cell lysate.

Western Blot Analysis: 0.5 µg/mL of this antibody detected Sirt5 on 10 µg of HeLa cell lysate.

Opis wartości docelowych

~34 kDa observed. Two isoforms at ~33 and ~34 kDa are known to exist.

Inne uwagi

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
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Kod klasy składowania

12 - Non Combustible Liquids

Klasa zagrożenia wodnego (WGK)

WGK 1

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Certyfikaty analizy (CoA)

Poszukaj Certyfikaty analizy (CoA), wpisując numer partii/serii produktów. Numery serii i partii można znaleźć na etykiecie produktu po słowach „seria” lub „partia”.

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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Profiling deacetylase activities in cell lysates with peptide arrays and SAMDI mass spectrometry.
Kuo, HY; DeLuca, TA; Miller, WM; Mrksich, M
Analytical Chemistry null
Mark T Duncan et al.
Experimental cell research, 344(1), 40-52 (2016-04-18)
Inhibition of histone deacetylases (HDACi) has emerged as a promising approach in the treatment of many types of cancer, including leukemias. Among the HDACs, Class III HDACs, also known as sirtuins (SIRTs), are unique in that their function is directly
Jarrod Flax et al.
Journal of Alzheimer's disease : JAD, 78(4), 1743-1753 (2020-12-09)
Alzheimer's disease (AD) features reductions in key bioenergetic fluxes and perturbed mitochondrial function. Cytoplasmic hybrids (cybrids) generated through the transfer of AD subject mitochondria to mtDNA-depleted SH-SY5Y neuroblastoma cells recapitulate some of these features in an in vitro setting. For
Elena Sidorova-Darmos et al.
Frontiers in aging neuroscience, 6, 333-333 (2015-01-08)
The sirtuins are NAD(+)-dependent protein deacetylases and/or ADP-ribosyltransferases that play roles in metabolic homeostasis, stress response and potentially aging. This enzyme family resides in different subcellular compartments, and acts on a number of different targets in the nucleus, cytoplasm and

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