677175-M

Vinblastine Sulfate

Antitumor alkaloid drug.

• Synonim(y): Vinblastine Sulfate
• Wzór empiryczny (zapis Hilla): C₄₆H₅₈N₄O₉ · xH₂SO₄
• Numer CAS: 143-67-9
• Masa cząsteczkowa: 810.97 (free base basis)
• UNSPSC Code: 12352200
• MDL number: MFCD00082457
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: crystalline solid
• Quality level: 100
• Storage condition: OK to freeze, desiccated, protect from light

Właściwości

• Quality Level: 100
• description: Merck USA index - 14, 9982
• assay: ≥98% (HPLC)
• form: crystalline solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, desiccated, protect from light
• color: white
• solubility: water: 50 mg/mL
• storage temp.: 2-8°C
• SMILES string: [S](=O)(=O)(O)O.N21C[C@H](C[C@@](C2)(O)CC)C[C@@](c8[nH]c9c(c8CC1)cccc9)(c3cc4c(cc3OC)N([C@@H]5[C@]64[C@H]7N(CC6)CC=C[C@]7([C@H]([C@]5(O)C(=O)OC)OC(=O)C)CC)C)C(=O)OC
• InChI: 1S/C46H58N4O9.H2O4S/c1-8-42(54)23-28-24-45(40(52)57-6,36-30(15-19-49(25-28)26-42)29-13-10-11-14-33(29)47-36)32-21-31-34(22-35(32)56-5)48(4)38-44(31)17-20-50-18-12-16-43(9-2,37(44)50)39(59-27(3)51)46(38,55)41(53)58-7;1-5(2,3)4/h10-14,16,21-22,28,37-39,47,54-55H,8-9,15,17-20,23-26H2,1-7H3;(H2,1,2,3,4)/t28-,37+,38-,39-,42+,43-,44-,45+,46+;/m1./s1
• InChI key: KDQAABAKXDWYSZ-JKDPCDLQSA-N

Opis

General description

Antitumor alkaloid drug. Induces apoptosis in cultured hepatocytes and human lymphoma cells. Affects interaction of tubulin with microtubule-associated proteins, specifically Tau and MAP2. Depolymerizes microtubules. Increases the frequency of micronucleated erythrocytes.

Biochem/physiol Actions

Primary Target
Interaction of tubulin with microtubule-associated proteins, specifically Tau and MAP2

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Tanaka, E., et al. 1995. J. Cell. Biol.128, 139.
Boscoboinik, D., et al. 1994. Biochem. Biophys. Res. Commun.199, 374.
Smith, C.D., et al. 1994. Cancer Lett.79, 213.
Smith, C.D., et al. 1994. Cancer Res.54, 3779.
Tsukidate, K., et al. 1993. Am. J. Pathol. 143, 198.
Jagetia, G.C., and Jacob, P.S. 1992. Mutat. Res.280, 87.
Jordan, M.A., et al. 1992. J. Cell Sci. 102, 401.
Prasad, V., et al. 1992. J. Protein Chem.11, 509.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

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Informacja o środkach bezpieczeństwa

• pictograms: GHS08,GHS07
• signalword: Warning
• hcodes: H302,H341,H361fd
• pcodes: P202 - P264 - P280 - P301 + P312 - P308 + P313 - P405
• Hazard Classifications: Acute Tox. 4 Oral - Muta. 2 - Repr. 2
• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3