559276

Ryanodine

≥98% (HPLC), solid, Ca2+ release blocker, Calbiochem^®

• Synonim(y): Ryanodine, High Purity
• Wzór empiryczny (zapis Hilla): C₂₅H₃₅NO₉
• Numer CAS: 15662-33-6
• Masa cząsteczkowa: 493.55
• MDL number: MFCD00151119
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: solid
• Quality level: 100
• Storage condition: OK to freeze, protect from light

Właściwości

• Nazwa produktu: Ryanodine, High Purity, Naturally occurring alkaloid that blocks the release of Ca²⁺ from the sarcoplasmic reticulum.
• description: Merck USA index - 14, 8307
• Quality Level: 100
• assay: ≥98% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, protect from light
• color: white
• solubility: water: 1 mg/mL, methanol: 20 mg/mL
• shipped in: ambient
• storage temp.: 10-30°C
• SMILES string: [nH]1c(ccc1)C(=O)O[C@H]2[C@@]3([C@]4([C@]65O[C@]([C@]4([C@@]2(O)C(C)C)C)(C[C@]3([C@]6(CC[C@@H]([C@H]5O)C)O)C)O)O)O
• InChI: 1S/C25H35NO9/c1-12(2)22(31)17(34-16(28)14-7-6-10-26-14)23(32)18(4)11-21(30)19(22,5)25(23,33)24(35-21)15(27)13(3)8-9-20(18,24)29/h6-7,10,12-13,15,17,26-27,29-33H,8-9,11H2,1-5H3/t13-,15+,17+,18-,19-,20-,21-,22+,23+,24+,25+/m0/s1
• InChI key: JJSYXNQGLHBRRK-YSOSZROBSA-N

Opis

General description

Naturally occurring alkaloid that blocks the release of Ca²⁺ from the sarcoplasmic reticulum. Has many complex effects on Ca²⁺ transport and action in muscle. Purified from Ryanodine Mixture.

Biochem/physiol Actions

Cell permeable: no

Primary Target
Ca2+ transport and action in muscle

Product does not compete with ATP.

Reversible: no

Preparation Note

Following reconstitution, refrigerate (4°C). Stock solutions are stable for up to 1 month at 4°C.

Other Notes

Sorrentino, V., and Volpe, P. 1993. Trends Pharmacol. Sci.14, 98.
Sabbadini, R., et al. 1992. J. Biol. Chem.267, 15475.
Feher, J.J., and Lipford, G.B. 1985. Biochim. Biophys. Acta813, 77.
Marban, E., and Wier, W.G. 1985. Circ. Res.56, 133.
Sukto, J.L., et al. 1985. Fed. Proc.44, 2984.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful (C)

Ta strona może zawierać tekst przetłumaczony maszynowo.

Informacja o środkach bezpieczeństwa

• pictograms: GHS07,GHS09
• signalword: Warning
• hcodes: H302 + H312,H410
• pcodes: P264 - P273 - P280 - P301 + P312 - P302 + P352 + P312 - P362 + P364
• Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1
• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable