557450

Ruthenium Red

Calcium channel blocker, solid

• Synonim(y): Ruthenium Red, Ammoniated Ruthenium Oxychloride, RR
• Wzór liniowy: [(NH₃)₅RuORu(NH₃)₄ORu(NH₃)₅]Cl₆
• Numer CAS: 12790-48-6
• MDL number: MFCD00270912
• NACRES: NA.77
• UNSPSC Code: 12352200
• Form: solid
• Storage condition: OK to freeze, desiccated

Właściwości

• Nazwa produktu: Ruthenium Red, A blocker of transmembrane Ca²⁺ fluxes (IC₅₀ = 7 µM) that attenuates capsaicin-induced cation channel opening.
• Quality Segment: 100
• description: Merck USA index - 14, 8300
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, desiccated
• color: red-black
• solubility: ammonia: soluble, water: soluble
• shipped in: ambient
• storage temp.: 10-30°C

Opis

General description

A blocker of transmembrane Ca²⁺ fluxes (IC₅₀ = 7 µM) that attenuates capsaicin-induced cation channel opening. Inhibits Ca²⁺-induced Ca²⁺ release from ryanodine-sensitive intracellular Ca²⁺ stores. Inhibits K⁺-stimulated catecholamine secretion (IC₅₀ = 6 µM).

Biochem/physiol Actions

Cell permeable: no

Primary Target
Blocker of transmembrane Ca2+ fluxes

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 7 µM in blocking transmembrane Ca2+ fluxes; 6 µM inhibiting K+-stimulated catecholamine secretion

Other Notes

Merck Index 13, 8379.
Phillippe, M. and Basa, A. 1996. Biochem. Biophys. Res. Commun. 221, 656.
Buratti, R., et al. 1995. Biochem. Biophys. Res. Commun. 213, 1082.
Hamilton, M.G. and Lundy, P.M. 1995. J. Pharmacol. Exp. Ther. 273, 940.
Gomis, A., et al. 1994. Biochem. Pharmacol. 47, 225.
Stjame, P., et al. 1994. Acta Otolaryngol. 114, 651.
Ma, J. 1993. J. Gen. Physiol.102, 1031.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful (C)

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Informacja o środkach bezpieczeństwa

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable