538904

Prostaglandin E₂

>98% (HPLC), MAP kinase inhibitor, solid

• Synonim(y): Prostaglandin E₂, PGE₂
• Wzór empiryczny (zapis Hilla): C₂₀H₃₂O₅
• Numer CAS: 363-24-6
• Masa cząsteczkowa: 352.47
• UNSPSC Code: 12352211
• NACRES: NA.77
• MDL number: MFCD00077861
• eCl@ss: 42020658
• Assay: >98% (HPLC)
• Form: solid
• Quality level: 100
• Storage condition: OK to freeze

Właściwości

• Nazwa produktu: Prostaglandin E₂, Involved in vasodilator actions of kinins such as bradykinin.
• Quality Level: 100
• description: Merck USA index - 14, 7877
• assay: >98% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: white to light yellow
• solubility: acetone: soluble, ethanol: soluble, ethyl acetate: soluble, methanol: soluble
• shipped in: wet ice
• storage temp.: −20°C
• SMILES string: OC1C(C(C(=O)C1)C\C=C\CCCC(=O)O)\C=C\C(O)CCCCC
• InChI: 1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4+,13-12+
• InChI key: XEYBRNLFEZDVAW-RTYMFESYSA-N

Opis

General description

Involved in vasodilator actions of kinins such as bradykinin. Inhibits MAP kinase in rat mesangial cells (IC₅₀ = 25-50 µM). Regulates the activity of adenylate cyclase via G-protein coupled receptors.

Biochem/physiol Actions

Cell permeable: no

Primary Target
Involved in vasodilator actions of kinins such as bradykinin

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 25-50 µM inhibiting MAP kinase in rat mesangial cells

Other Notes

Li, X., et al. 1995. Am. J. Physiol.269, C986.
Kessler, W., et al. 1992. Exp. Brain Res.91, 467.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful (C)

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Informacja o środkach bezpieczeństwa

• pictograms: GHS08,GHS07
• signalword: Danger
• hcodes: H302,H360FD
• pcodes: P202 - P264 - P280 - P301 + P312 - P308 + P313 - P405
• Hazard Classifications: Acute Tox. 4 Oral - Repr. 1B
• Klasa składowania: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3