524748

PDE4D Inhibitor, GEBR-7b

The PDE4D Inhibitor, GEBR-7b controls the biological activity of PDE4D. This small molecule/inhibitor is primarily used for Cell Signaling applications.

• Synonim(y): PDE4D Inhibitor, GEBR-7b, GEBR-7b, (E)-3-(cyclopentyloxy)-4-methoxybenzaldehyde, O-2-(2,6-dimethylmorpholino)-2-oxoethyl oxime
• Wzór empiryczny (zapis Hilla): C₂₁H₃₀N₂O₅
• Numer CAS: 1349848-90-3
• Masa cząsteczkowa: 390.47
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD28053503
• Assay: ≥95% (HPLC)
• Form: semisolid
• Storage condition: OK to freeze, protect from light

Właściwości

• Quality Segment: 100
• assay: ≥95% (HPLC)
• form: semisolid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, protect from light
• color: pale yellow
• solubility: DMSO: 100 mg/mL, clear, colorless
• shipped in: wet ice
• storage temp.: −20°C
• SMILES string: COC1=C(OC2CCCC2)C=C(/C([H])=N/OCC(N3CC(C)OC(C)C3)=O)C=C1
• InChI key: JEXHQZPMUKFOIV-SSDVNMTOSA-N

Opis

General description

A cell permeable, potent, and selective oxime PDE4D inhibitor (IC₅₀ = 0.67 µM) which displays much reduced activities toward other PDE4 isoforms. It is shown to cause a significant 40% increase in extracellular cAMP in the hippocampus of freely moving rats in vivo at 100 µM, but has no effect on Aβ levels. This compound elicits cognitive enhancement in vivo at the optimum dose of 0.003 mg/kg in both mice and rat models, and unlike rolipram, does not cause emesis-like behavior in rodents.

Packaging

Packaged under inert gas

Other Notes

Bruno, O., et al. 2011. Br. J. Pharmacol.in press.
Bruno, O., et al. 2009. J. Med. Chem.52, 6546.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Ta strona może zawierać tekst przetłumaczony maszynowo.

Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable