362339

Glyco-SNAP-2

A water-soluble nitric oxide (NO) donor that exhibits greater stability (t1/2 = 27 hours) than that of SNAP.

• Synonim(y): Glyco-SNAP-2, N-(2-Deoxy-α,β-D-glucopyranose-2-)-N²-acetyl-S-nitroso-D,L-penicillaminamide
• Wzór empiryczny (zapis Hilla): C₁₃H₂₃N₃O₈S
• Numer CAS: 188849-82-3
• Masa cząsteczkowa: 381.40
• UNSPSC Code: 12352200
• NACRES: NA.77
• PubChem Substance ID: 3413551
• Assay: ≥95% (HPLC)
• Form: solid
• Storage condition: OK to freeze, protect from light

Właściwości

• Quality Segment: 100
• assay: ≥95% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, protect from light
• color: green
• solubility: aqueous buffer: >100 mg/mL, methanol: soluble, water: soluble
• shipped in: ambient
• storage temp.: −20°C
• SMILES string: CC(=O)NC(C(=O)NC1C(C(C(OC1O)CO)O)O)C(C)(C)SN=O
• InChI: 1S/C13H23N3O8S/c1-5(18)14-10(13(2,3)25-16-23)11(21)15-7-9(20)8(19)6(4-17)24-12(7)22/h6-10,12,17,19-20,22H,4H2,1-3H3,(H,14,18)(H,15,21)
• InChI key: MPJKBQQBYUJGPA-UHFFFAOYSA-N

Opis

General description

A nitric oxide donor that exhibits greater stability than SNAP in aqueous medium, in both the presence and absence of EDTA. The half life of Glyco-SNAP-2 in aqueous medium is 27.4 h at room temperature, in the absence of EDTA, compared to 10.3 h for SNAP. The compound consists of a S-nitroso-N-acetylpencilamine moiety, which acts as a NO-donor, and a sugar fragment, which provides the desired hydrophobicity.

A water-soluble nitric oxide (NO) donor that exhibits greater stability (t_½ = 27 hours) than that of SNAP. Exhibits properties similar to those of Glyco-SNAP-1 (Cat. No. 362338).

Biochem/physiol Actions

Cell permeable: no

Primary Target
Water-soluble nitric oxide (NO) donor

Product does not compete with ATP.

Reversible: no

Preparation Note

Unstable in solution; reconstitute just prior to use.

Other Notes

Hou, Y., et al. 1999. Methods Enzymol. 301, 242.
Ramirez, J., et al. 1996. Bioorg. Med. Chem. Lett.6, 2575.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• flash_point_f: Not applicable
• flash_point_c: Not applicable