361554

TWS119

≥95% (HPLC), solid, GSK-3β inhibitor, Calbiochem^®

• Synonim(y): GSK-3β Inhibitor XII, TWS119, Neurogenesis Inducer, TWS119
• Wzór empiryczny (zapis Hilla): C₁₈H₁₄N₄O₂
• Numer CAS: 601514-19-6
• Masa cząsteczkowa: 318.33
• Numer MDL: MFCD09037535
• Kod UNSPSC: 12352200
• NACRES: NA.77

Właściwości

• product name: GSK-3β Inhibitor XII, TWS119, The GSK-3β Inhibitor XII, TWS119, also referenced under CAS 601514-19-6, controls the biological activity of GSK-3β. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
• Poziom jakości: 100
• Próba: ≥95% (HPLC)
• Postać: solid
• siła działania: 30 nM IC₅₀
• producent / nazwa handlowa: Calbiochem^®
• warunki przechowywania: OK to freeze; protect from light
• kolor: beige
• rozpuszczalność: methanol: 2 mg/mL; DMSO: 200 mg/mL
• Warunki transportu: ambient
• temp. przechowywania: 2-8°C
• InChI: 1S/C18H14N4O2/c19-12-4-1-3-11(7-12)16-9-15-17(22-16)20-10-21-18(15)24-14-6-2-5-13(23)8-14/h1-10,23H,19H2,(H,20,21,22)
• Klucz InChI: VPVLEBIVXZSOMQ-UHFFFAOYSA-N

Opis

Opis ogólny

A cell-permeable and potent inhibitor of GSK-3β (IC₅₀ = 30 nM). Binds to GSK-3β with high-affinity (K_d = 126 nM), leading to an increase in the level of β-catenin, a downstream substrate of GSK-3β in the Wnt signaling pathway. Shown to selectively induce neuronal differentiation in both pluripotent murine embryonal carcinoma cells (P19; 30-40% at 1 µM) and embryonic stem cells (D3; 50-60% at 400 nM).

A cell-permeable pyrrolopyrimidine compound that acts as a potent inhibitor of GSK-3β (IC₅₀ = 30 nM). Binds to GSK-3β with high-affinity (K_d = 126 nM) and increases the level of β-catenin, a downstream substrate of GSK-3β in the Wnt signaling pathway. Shown to selectively induce neuronal differentiation in both pluripotent murine embryonal carcinoma cells (P19; 30-40% at 1 µM) and embryonic stem cells (D3; 50-60% at 400 nM).

Działania biochem./fizjol.

Cell permeable: yes

Kd = 126 nM against GSK-3β

Primary Target
GSK-3β

Product does not compete with ATP.

Reversible: no

Opakowanie

Packaged under inert gas

Ostrzeżenie

Toxicity: Carcinogenic / Teratogenic (D)

Rekonstytucja

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Inne uwagi

Ding, S., et al. 2003. Proc. Natl. Acad. Sci. USA100, 7632.

Informacje prawne

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3